Development of palminp-sizedbiochemical analysis system based on magnetic beads handling

我们利用MEMS技术开发了一套掌上电脑大小的全分析系统。研究结果如下：(1)建立了搬运微珠的动力学模型，明确了界面张力与磁力之间的关系。研究中还对处理的尺度效应进行了解释。(2)利用MEMS技术开发了分析器件的制作工艺。该装置由有机硅树脂制成，其全表面涂覆一层聚对二甲苯薄膜，形成疏水性。(3)通过磁珠处理，确定了装置的生化处理、反应、提取和稀释。我们还通过控制磁场来提高搅拌性能，并用多层扁平线圈对磁场进行了修饰。(4)应用酶反应验证了生化反应的性能，并利用旋转驱动机制开发了掌上电脑大小的系统。

We developed a palmtop-sized total analysis system by using MEMS technologies. The, obtained results are in the followings.(1) We constructed the dynamic model for beads handling, and cleared the relationship between the interface tension and the magnetic driving force. The scale effect for the handling was also explained in the research.(2) We developed the fabrication process of analysis devices by MEMS technologies. The devices were fabricated by the silicone resin, and their all surface was coated by the parylene film to form the hydrophobic nature.(3) We confirmed the biochemical treatments, reaction, extraction, and dilution, on the developed devices by applying magnetic beads handling. We also developed the agitation performance by controlling magnetic field, which was modified by the multilayered flat coils.(4) We confirmed the performance of biochemical reactions by applying the enzymatic reaction, and finally developed the palmtop-sized system by using rotational driving mechanism.