Development of palminp-sizedbiochemical analysis system based on magnetic beads handling

我们利用MEMS技术研制了一个掌上型全分析系统。所得结果如下。(1)建立了微珠搬运的动力学模型，明确了界面张力与磁驱动力之间的关系。研究中还解释了处理的规模效应。(2)开发了基于MEMS技术的分析器件制作工艺。该器件由硅树脂制成，并在其整个表面涂覆聚对二甲苯膜以形成疏水性。(3)我们确认了生物化学处理，反应，提取和稀释，在开发的设备上，通过应用磁珠处理。通过控制磁场的大小来改善搅拌性能，并通过多层扁平线圈来改善搅拌性能。(4)我们应用酶促反应来验证生化反应的效能，最后利用旋转驱动机制，开发出掌上型的系统。

We developed a palmtop-sized total analysis system by using MEMS technologies. The, obtained results are in the followings.(1) We constructed the dynamic model for beads handling, and cleared the relationship between the interface tension and the magnetic driving force. The scale effect for the handling was also explained in the research.(2) We developed the fabrication process of analysis devices by MEMS technologies. The devices were fabricated by the silicone resin, and their all surface was coated by the parylene film to form the hydrophobic nature.(3) We confirmed the biochemical treatments, reaction, extraction, and dilution, on the developed devices by applying magnetic beads handling. We also developed the agitation performance by controlling magnetic field, which was modified by the multilayered flat coils.(4) We confirmed the performance of biochemical reactions by applying the enzymatic reaction, and finally developed the palmtop-sized system by using rotational driving mechanism.