Research on micromachine technology for transplantation surgery based on tissue engineering

基于组织工程的移植手术微机械技术研究

• 批准号: 21300173
• 负责人: KONISHI Satoshi
• 金额: $ 11.98万
• 依托单位: Ritsumeikan University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300173/
• 关键词: 再生医療移植技術; マイクロマシン; 細胞シート; バルーンアクチュエータ; S3マイクロマシ; S3マイクロマシン; バルーンアクチュエー

Recently, transplantation surgery based on tissue engineering is strongly expected to cure inextirpable disease or congenital failure effectively. Transplantation surgery in an eye is one of the most challenging medical technologies because an eye has only tiny surgical field and is very fragile. Therefore, it is expected to develop the minimally inversion medical technology for transplantation surgery in an eye. We have interested in the Retinal Pigment Epithelium(RPE) sheet transplantation and developed a transplantation surgical tool using pneumatic balloon actuator(PBA).Toward design optimization of pneumatic balloon actuators(PBAs), we have performed FEM simulation and demonstrated its applicability to compute and characterize the bending motion of PBAs fabricated from PDMS(polydimethylsiloxane)-based materials. It is shown that typical PBA motions could be successfully captured in the present simulation through the comparison of the computational results obtained in the linearly-elastic region with the actual motions of fabricated devices. Successive ex-vivo and in-vivo experiments through collaborations will verify the practical usability of the improved tool.

近年来，以组织工程为基础的移植手术有望有效地治疗疑难杂症或先天性疾病。眼内移植手术是最具挑战性的医疗技术之一，因为眼睛只有很小的手术区域，而且非常脆弱。因此，期望开发用于眼内移植手术的最小内翻医疗技术。我们对视网膜色素上皮（Retinal Pigment Epithelium，RPE）薄片移植手术的研究和开发了一种基于气动气囊驱动器（pneumatic balloon actuator，PBA）的视网膜色素上皮薄片移植手术工具，针对气动气囊驱动器的优化设计，我们进行了有限元模拟，并证明了其适用性，以计算和表征由聚二甲基硅氧烷（polydimethylsiloxane，PDMS）基材料制成的PBA的弯曲运动。结果表明，典型的PBA运动可以成功地捕捉在本模拟中，通过比较的计算结果中得到的线弹性区域与制造设备的实际运动。通过合作进行的连续体外和体内实验将验证改进工具的实际可用性。

项目成果

Micromachine for DDS

DDS微机

• 发表时间: 2011
• 作者: 桂啓志;水本将之;大貝猛;香川明男;田川泰;小西聡
• 通讯作者: 小西聡

FEM解析に基づいたPDM S製圧力駆動バルーンアクチュエータの変形動作シミュレーション

基于FEM分析的PDM S压力驱动球囊执行器变形运动仿真

• 发表时间: 2011
• 作者: 森本賢一;内海周;小西聡
• 通讯作者: 小西聡

A design of longitudinally-divided balloon structure in PDMS pneumatic balloon actuator based on fem simulations

• DOI: 10.1109/transducers.2011.5969597
• 发表时间: 2011-06
• 期刊: 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference
• 作者: K. Morimoto;A. Utsumi;S. Konishi

Surface Adhesion Control of Patterned Perfluoro Polymer for Release Technology in theμTAS Fabrication Process

μTAS 制造过程中用于脱模技术的图案化全氟聚合物的表面粘附控制

• 发表时间: 2009
• 期刊: 電気学会論文誌E
• 作者: 桂啓志;水本将之;大貝猛;香川明男;田川泰;T. Kobayashi and S. Konishi
• 通讯作者: T. Kobayashi and S. Konishi

Formation of superhydrophobic/superhydrophilic patterns by combination of nanostructure-imprinted perfluoropolymer and nanostructured silicon oxide for biological droplet generation

• DOI: 10.1063/1.3570627
• 发表时间: 2011-03-21
• 期刊: APPLIED PHYSICS LETTERS
• 影响因子: 4
• 作者: Kobayashi, Taizo;Shimizu, Kazunori;Konishi, Satoshi
• 通讯作者: Konishi, Satoshi