ANALYSIS OF IMMUNOLOGICAL TARGET MOLECULES FOR MOLECULAR PREVENTION OF ASBESTOS-RELATED TUMOR FORMATIONIN CASES WHO EXPOSED ASBESTOS

众所周知，接触石棉会导致石棉相关疾病，如石棉肺、肺癌和恶性间皮瘤(MM)，不仅在工作环境中接触过石棉的人会如此，在处理石棉的工厂附近居住的居民也会如此。自2005年夏天以来，这些事实一直是日本的一个巨大的医疗和社会问题。我们关注石棉和二氧化硅对人体免疫系统的影响。在这篇简短的综述中，我们介绍了多发性骨髓瘤患者的免疫学变化，并概述了它们的实验检测。如MM患者存在CD_4~+T细胞bc1-2高表达，血浆中高水平的干扰素(L)-10和转化生长因子-β，CD_3~+T细胞存在T细胞受体-Vβ的多重过度表达。我们还详细介绍了一个实验性的长期暴露T细胞模型。分析石棉的免疫学效应可能有助于我们理解石棉的生物效应。免疫分子研究的最新进展导致了对石棉免疫效应的详细分析。石棉影响免疫活性细胞，这些影响可能与石棉暴露患者并发症(如恶性肿瘤)的病理生理发展有关。此外，免疫学分析可能导致发现新的临床工具，用于改变疾病的病理生理学方面，如使用细胞-MEDLATED疗法、各种细胞因子和分子靶向疗法调节肿瘤免疫。随着与石棉相关的恶性肿瘤发病率的增加，自2005年夏天以来，日本对此类恶性肿瘤造成的医疗和社会问题日益关注，应将工作重点放在开发治疗这些疾病的方法上，以消除全国对这些恶性肿瘤的担忧。

IT IS COMMON KNOWLEDGE THAT ASBESTOS EXPOSURE CAUSES ASBESTOS-RELATED DISEASES SUCH AS ASBESTOSIS, LUNG CANCER AND MALIGNANT MESOTHELIOMA (MM) NOT ONLY IN PEOPLE WHO HAVE HANDLED ASBESTOS IN THE WORK ENVIRONMENT, BUT ALSO IN RESIDENTS LIVING NEAR FACTORIES THAT HANDLE ASBESTOS. THESE FACTS HAVE BEEN AN ENORMOUS MEDICAL AND SOCIAL PROBLEM IN JAPAN SINCE THE SUMMER OF 2005. WE FOCUSED ON THE IMMUNOLOGICAL EFFECTS OF ASBESTOS AND SILICA ON THE HUMAN IMMUNE SYSTEM IN THIS BRIEF REVIEW, WE PRESENT IMMUNOLOGICAL CHANGES IN PATIENTS WITH MM AND OUTLINE THEIR EXPERIMENTAL DETECTION. FOR EXAMPLE, THERE IS OVER-EXPRESSION OF BCL-2 IN CD4+ PERIPHERAL T CELLS, HIGH PLASMA CONCENTRATIONS OF INI'ERLEUKIN (L)-l0 AND TRANSFORMING GROWTH FACTOR (TGF)-β AND MULTIPLE OVER ON OF T CELL RECEPTOR (TCR)-Vβ IN PERIPHERAL CD3+ T CELLS FOUND IN MM PATIENTS. WE ALSO DETAIL AN EXPERIMENTAL LONGTERM EXPOSURE T-CELL MODEL. ANALYSIS OF THE IMMUNOLOGICAL EFFECTS OF ASBESTOS MAY HELP OUR UNDERSTANDING OF THE BIOLOGICAL EFFECTS OF ASBESTOS. RECENT ADVANCES IN IMMUNOMOLECULAR STUDIES HAVE LED TO DETAILED ANALYSES OF THE IMMUNOLOGICAL EFFECTS OF ASBESTOS. ASBESTOS AFFECTS IMMUNOCOMPETENT CELLS AND THESE EFFECTS MAY RE ASSOCIATED WITH THE PATHOPHYSIOLOGICAL DEVELOPMENT OF COMPLICATIONS IN ASBESTOS-EXPOSED PATIENTS SUCH AS MALIGNANT TUMORS. IN ADDITION, IMMUNOLOGICAL ANALYSES MAY LEAD TO THE DISCOVERY OF NEW CLINICAL TOOLS FOR THE MODIFICATION OF PATHOPHYSIOLOGICAL ASPECTS OF DISEASES, SUCH AS THE REGULATION OF TUMOR IMMUNITY USING CELL-MEDLATED THERAPIES, VARIOUS CYTOKINES AND MOLECULE-TARGETING THERAPIES. AS THE INCIDENCE OF ASBESTOS-RELATED MALIGNANCIES INCREASES AGAINST THE GROWING CONCERN IN JAPAN SINCE THE SUMMER OF 2005 FOR MEDICAL AND SOCIAL PROBLEMS CREATED BY SUCH MALIGNANCIES, EFFORTS SHOULD RE FOCUSED ON DEVELOPING A CURE FOR THESE DISEASES IN ORDER TO ELIMINATE THE NATIONWIDE ANXIETY CONCERNING THESE MALIGNANCIES.