Anaylisis of immunological alterations affecting asbestos-induced carcinogenesis

自从2005年所谓的久保田休克以来，石棉接触者的致癌问题一直是医学和社会问题。该项目的目的是阐明接触石棉是否会影响人体免疫系统，从而导致致癌。因此，我们的大多数发现表明，使用人类细胞系和新分离的免疫细胞暴露于石棉引起的免疫改变会降低肿瘤免疫力。寻找关于石棉免疫效应的分子预防靶点应在未来进行。

Since so-called "Kubota-Shock" in 2005, the issue regarding carcinogenesis among the patients exposed to asbestos has been medical and social problem. The aim of this project is to elucidate whether or not asbestos exposure affect on human immune system to tend to induce carcinogenesis. As the results, most of our findings indicate immune alteration caused by asbestos exposure using human cell lines and freshly isolated immune cells proceed to reducing tumor immunity. To find molecular preventive targets regarding immunological effects of asbestos should be performed in the future.