Analysis of immunoreactivity against glycoproteins with disialosyl residue in neuroimmunological diseases
Analysis of immunoreactivity against glycoproteins with disialosyl residue in neuroimmunological diseases
批准号:
18390264
负责人:
KUSUNOKI Susumu
金额:
$11.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2008
中文摘要
ジシアロシル基をもつGD1b感作によるウサギ失調性ニューロパチ-モデルにおいて、後根神経節細胞のアポトーシスを確認した GD1bにきわめて特異的な抗体が失調の病態に関連することを示した Fisher症候群および関連疾患で、GQ1bを含むガングリオシド複合体に特異的抗体の存在を見出した。ジシアロシル基に反応する抗体と神経組織のタンパク成分の反応をWestern blottingで認めた。
英文摘要
ジシアロシル基をもつGD1b感作によるウサギ失調性ニューロパチ-モデルにおいて、後根神経節細胞のアポトーシスを確認した GD1bにきわめて特異的な抗体が失調の病態に関連することを示した Fisher症候群および関連疾患で、GQ1bを含むガングリオシド複合体に特異的抗体の存在を見出した。ジシアロシル基に反応する抗体と神経組織のタンパク成分の反応をWestern blottingで認めた。
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Complete recovery of an aged patient with Guillain-Barre syndrome associated with multiple IgM anti-ganglioside antibodies
伴有多种 IgM 抗神经节苷脂抗体的老年格林巴利综合征患者完全康复
DOI:
--
发表时间:
2008
期刊:
Muscle Nerve 38
影响因子:
--
作者:
[Furiya Y, Hirano M, Kusunoki S, Ueda M, Sugie K, Nishiwaki T, Ueno S.]
通讯作者:
Ueno S.
DOI:
10.1212/01.wnl.0000335160.72184.7d
发表时间:
2008-11-18
期刊:
NEUROLOGY
影响因子:
9.9
作者:
[Kaida, K., Sonoo, M., Kusunoki, S.]
通讯作者:
Kusunoki, S.
Complete recovery of an aged patient with Guillain-Barre syndorme associated with multiple IgM anti-ganglioside antibodies
伴有多种 IgM 抗神经节苷脂抗体的老年格林-巴利综合征患者完全康复
DOI:
--
发表时间:
2008
期刊:
Muscle Nerve 38
影响因子:
--
作者:
[Kaida K, Kusunoki S, Kanzaki M, Kaida K, Kaida K, Furiya Y]
通讯作者:
Furiya Y
Anti-ganglioside complex antibodies in Miller Fisher syndrome and Guillain-Barre syndrome with ophthalmoplegia
米勒·费希尔综合征和吉兰-巴利综合征伴眼肌麻痹的抗神经节苷脂复合物抗体
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Tomizawa D, Mizutani S., et. al., Kaida K]
通讯作者:
Kaida K
IgG antibody highly specific to GD1b is specifically associated with ataxia in Guillain-Barre syndrome
GD1b 高度特异性的 IgG 抗体与格林-巴利综合征的共济失调特异性相关
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Tomizawa D, Mizutani S., et. al., Kaida K, Shuki Mizuani, Kusunoki S]
通讯作者:
Kusunoki S
共 38 条
Investigation of the autoantibodies against complex antigens formed by two lipid molecules in neuroimmunological diseases
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批准号:18H02745
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.98万
-
财政年份:2018
-
负责人:KUSUNOKI Susumu
-
依托单位:
Analysis of target antigens and pathogenetic mechanisms of neuroimmunological diseases using glycoarray
-
批准号:15H04845
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.15万
-
财政年份:2015
-
负责人:KUSUNOKI Susumu
-
依托单位:
Analysis of negative regulators of B lymphocyte responses to glycoconjugates in neuroimmunological diseases
-
批准号:24390225
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.32万
-
财政年份:2012
-
负责人:KUSUNOKI Susumu
-
依托单位:
Analysis of the neuropathogenic mechanisms induced by the antiganglioside antibodies : the effect on signal transduction in neurons
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批准号:21390273
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.23万
-
财政年份:2009
-
负责人:KUSUNOKI Susumu
-
依托单位:
Investigation on the immune reactions against complex antigens including gangliosides in the neuroimmunological diseases
-
批准号:16590854
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2004
-
负责人:KUSUNOKI Susumu
-
依托单位:
Investigation on the significance of the epitope formed by ganglioside and phospholipid in neuroimmunological diseases
-
批准号:14570581
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2002
-
负责人:KUSUNOKI Susumu
-
依托单位:
Development of axonal degeneration by passive transfer of antiganglioside antibody and therapeutic trial for it.
-
批准号:12670595
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.43万
-
财政年份:2000
-
负责人:KUSUNOKI Susumu
-
依托单位:
Identification of a ganglioside localized in paranodal region of peripheral nerve and induction of experimental autoimmune neuropathy
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批准号:10670576
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:1998
-
负责人:KUSUNOKI Susumu
-
依托单位:
Investigation on the pathogenetic mechanism of GD1b-induced experimental neuropathy and approach to effective treatment
-
批准号:08670695
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.6万
-
财政年份:1996
-
负责人:KUSUNOKI Susumu
-
依托单位:
Identification and localization of minor glycolipid antigens recognized by serum antibody in Guillain-Barre' syndrome
-
批准号:05670551
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:1993
-
负责人:KUSUNOKI Susumu
-
依托单位:
海外基金