Development of axonal degeneration by passive transfer of antiganglioside antibody and therapeutic trial for it.

抗神经节苷脂抗体被动转移引起的轴突变性及其治疗试验。

• 批准号: 12670595
• 负责人: KUSUNOKI Susumu
• 金额: $ 2.43万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670595/
• 关键词: Guillain-Barre syndrome.; ganglioside; neuropathy; autoimmunity; glycolipid; neuroimmunology; ataxia; demyelination; モラン・バレー症候群

We previously reported the development of sensory ataxic neuropathy (SAN) in rabbits sensitized with GD 1b ganglioside. To investigate the pathogenetic role of anti-GD 1b antibody, we performed intravenous infusion of anti-GD 1b antiserum from the affected rabbits into normal rabbits. It produced axonal degeneration with macrophage infiltration in primary sensory neurons with central axons extending to the dorsal column, the same pathological findings for GD 1b-induced SAN, showing that anti-GD 1b antibody is an important pathogenetic factor in this animal model Guillain-Barre syndrome (GBS) with monospecific IgG anti-GD 1b antibody was associated with disturbance in deep sensation and demyelinating form. GD 1b is localized in large primary sensory neurons and paranodal myelin. Monospecific anti-GD 1b antibody may bind to those regions and cause the above clinical features. Anti-Gal-C antibodies are present in the acute-phase sera from GBS patients subsequent to M. pneumoniae. We showed that a Gal-C-like structure is present in M. pneumoniae, indicative of molecular mimicry between a major myelin glycolipid, Gal-C, and M. pneumoniae.

我们先前报道了GD 1b神经节苷脂致敏家兔感觉性共济失调性神经病（SAN）的发生。为探讨抗GD 1b抗体在该病发病中的作用，我们将患兔抗GD 1b抗血清静脉输注给正常兔。GD 1b诱导的SAN病理结果与GD 1b诱导的SAN相同，表明抗GD 1b抗体是该动物模型的重要致病因素，单特异性IgG抗GD 1b抗体与深部感觉障碍和脱髓鞘形式有关。GD 1b定位于大型初级感觉神经元和结旁髓鞘中。单特异性抗GD 1b抗体可能与这些区域结合并导致上述临床特征。抗Gal-C抗体存在于M.肺炎。结果表明，M. pneumoniae，指示主要髓鞘糖脂Gal-C和M之间的分子模拟。肺炎。

项目成果

Kaida K, Kusunoki S, Kamakura K, Motoyoshi K, Kanazawa I.: "Guillain-Barre syndrome with antibody to a ganglioside N-acetylgalactosaminyl GD1a."Brain. 123. 116-124 (2000)

Kaida K、Kusunoki S、Kamakura K、Motoyoshi K、Kanazawa I.：“具有神经节苷脂 N-乙酰半乳糖胺基 GD1a 抗体的格林-巴利综合征。”大脑。

Shiina M, Kusunoki K, Miyazaki T, kanazawa I.: "Variability in immunohistochemistries of IgM M-proteins binding to sulfatsd glucuronyl paragloboside"J Neuroimmunol. 116. 206-212 (2001)

Shiina M、Kusunoki K、Miyazaki T、kanazawa I.：“IgM M 蛋白与硫酸酯葡萄糖醛酸副红球苷结合的免疫组织化学变化”J Neuroimmunol。

Kaida K, Kusunoki S, et al.: "Guillain-Barre syndrome with antibody・・・"Brain. 123. 116-124 (2000)

Kaida K、Kusunoki S 等人：“带有抗体的格林-巴利综合征……”大脑。123. 116-124 (2000)

Miyazaki T, Kustmoki S, Kaida K, Shiina M, Kanazawa I.: "Guillain-Barre syndrome associated with IgG monospecific to ganglioside GD1b"Neurology. 56. 1227-1229 (2001)

Miyazaki T、Kustmoki S、Kaida K、Shiina M、Kanazawa I.：“与神经节苷脂 GD1b 单特异性 IgG 相关的吉兰-巴利综合征”神经病学。

Mizutani K, Oka N, Kusunoki S, et al.: "Sensorimotor demyelinating neuropathy with IgM antibody against gangliosides GD1a..."Journal of the Neurological Sciences. 188. 9-11 (2001)

Mizutani K、Oka N、Kusunoki S 等人：“针对神经节苷脂 GD1a 的 IgM 抗体引起的感觉运动脱髓鞘神经病……”神经科学杂志。