Analysis of the neuropathogenic mechanisms induced by the antiganglioside antibodies : the effect on signal transduction in neurons

此外，抗GD 1b抗体与感觉共济失调性神经病变的影响兔培养的兔背根神经节神经元引起的神经炎的形态学变化。来自轴突型格林-巴利综合征（GBS）患者的抗GM 1抗体直接影响脂筏的完整性并改变细胞中的信号转导。在脱髓鞘型GBS和慢性炎性脱髓鞘性多发性神经病患者血清中检测到抗LM 1（一种定位于人外周神经髓鞘的糖脂）和LM 1/GM 1和LM 1/GD 1b等神经节苷脂复合物的抗体。

Addition of the anti-GD1b antibodies from rabbits affected with sensory ataxic neuropathy to cultured rabbit dorsal root ganglia neurons caused morphological changes in the neuritis. Anti-GM1 antibodies from patients with axonal type of Guillain-Barre syndrome(GBS) directly influence the integrity of the lipid rafts and alter the signal transduction in the cells. Antibodies against LM1, a glycolipid localized in human peripheral nerve myelin, and such ganglioside complexes as LM1/GM1 and LM1/GD1b were detected in sera from patients with demyelinating type of GBS and chronic inflammatory demyelinating polyneuropathy.