Analysis of the neuropathogenic mechanisms induced by the antiganglioside antibodies : the effect on signal transduction in neurons

将感觉性共济失调性神经病兔的抗GD1b抗体加入培养的兔背根神经节神经元中，可引起神经炎的形态变化。轴索型格林-巴利综合征(GBS)患者的抗GM1抗体直接影响脂筏的完整性，改变细胞内的信号转导。在脱髓鞘型GBS和慢性炎症性脱髓鞘多发性神经病患者血清中检测到抗LM1抗体和神经节苷脂复合体LM1/GM1和LM1/GD1b。

Addition of the anti-GD1b antibodies from rabbits affected with sensory ataxic neuropathy to cultured rabbit dorsal root ganglia neurons caused morphological changes in the neuritis. Anti-GM1 antibodies from patients with axonal type of Guillain-Barre syndrome(GBS) directly influence the integrity of the lipid rafts and alter the signal transduction in the cells. Antibodies against LM1, a glycolipid localized in human peripheral nerve myelin, and such ganglioside complexes as LM1/GM1 and LM1/GD1b were detected in sera from patients with demyelinating type of GBS and chronic inflammatory demyelinating polyneuropathy.