Single nucleotide polymorphism (SNP) in COX-2 promoter gene:roles in the prevention of overactive bladder caused by cerebro-vascular accident or bladder outlet obstruction
COX-2启动子基因单核苷酸多态性(SNP)在预防脑血管意外或膀胱出口梗阻引起的膀胱过度活动症中的作用
基本信息
- 批准号:18390433
- 负责人:
- 金额:$ 10.77万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2006
- 资助国家:日本
- 起止时间:2006 至 2007
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
It has been reported that a new variant in the COX-2 promoter, a guanine to cytosine substitution at -765 (-765G->C) is located within a putative binding site for the transcription factor Spl. The polymorphism of the COX-2 gene was found to associate with a decreased risk of myocardial infarction and stroke by reduction in PGE2 production. Previously we reported that PGE2 played an important role in neuron-plasticity in the brain and spine, which resulted in the development of OAB. Therefore, in BPH or stroke patients with -765GC genotype or -765CC genotype, development of OAR in believed to be diminished. In the present study, the patients with cerebrovascular accident, spinal lesion, or bladder outlet obstruction (BOO) were classified into two groups ; overactive bladder (OAB) group and non-overactive bladder (non-OAB) group according to the International Prostate symptom Score (IPSS)/OAB symptom score. Blood and urine samples were collected from all patients. Gemonic DNA was prepare … More d from blood and -765G->C variant was genotyped by restriction endonuclease digestion of the polymerase chain reaction product. Genotypes were determined. The level of prostaglandin E2 (PGE2) in the urine were analyzed with the severity of OAB. The results obtained in 2006 and 2007 were as follows;1. The urine levels of PGE2 in patients with BOO were significantly higher than that in control.2. The urine level of PGE2 in patients with cerebrovascular accident was correlated with severity of IPSS. The patients with high score of IPSS reveals high level of urine PGE2.3. COX inhibitors dose-dependently inhibited detrusor overactivity caused by cerebral infarction in rats. This effect was dependent on suppression of C-fiver afferent nerves in the bladder.4. Single nucleotide polymorphism (SNP) in COX-2 promoter gene was found in 3 out of 70 patients with OAB. The results will be presented at 2008 NBS annual meeting in Tokyo. We have to accumulate the samples to analyze the correlation between SNP and severity of OAB.PGE2 excreted from the urothelium in response to bladder distension stimulates C-fiver afferent nerves, subsequently promoting detrusor overactivity. This mechanism seems to be true in patients with BOO. However, the levels of PGE2 were related with the severity of OAB in patients with cerebrovascular accidents. They were not proven to exist BOO. These results suggest that there might exist other underlying mechanisms to explain the role of PGE2 in OAB. Less
据报道,COX-2启动子中的一个新变体,即-765 (- 765g ->C)上的鸟嘌呤到胞嘧啶的替换,位于转录因子Spl的推定结合位点内。COX-2基因的多态性被发现与心肌梗死和中风的风险降低有关,通过减少PGE2的产生。先前我们报道PGE2在脑和脊柱的神经元可塑性中发挥重要作用,导致OAB的发展。因此,在-765GC基因型或-765CC基因型的BPH或脑卒中患者中,OAR的发展被认为是减少的。本研究将脑血管意外、脊髓病变或膀胱出口梗阻(BOO)患者分为两组;膀胱过动症(OAB)组和非膀胱过动症(非OAB)组根据国际前列腺症状评分(IPSS)/OAB症状评分。采集所有患者的血液和尿液样本。用限制性内切酶酶切聚合酶链反应产物对- 765g ->C变异体进行基因分型。测定基因型。分析尿中前列腺素E2 (PGE2)水平与OAB严重程度的关系。2006年和2007年的研究结果如下:BOO患者尿PGE2水平显著高于对照组。脑血管意外患者尿PGE2水平与IPSS严重程度相关。IPSS评分高的患者尿PGE2.3水平高。COX抑制剂剂量依赖性抑制脑梗死大鼠逼尿肌过度活动。这种效果依赖于对膀胱c - 5传入神经的抑制。70例OAB患者中有3例COX-2启动子基因单核苷酸多态性(SNP)。调查结果将在东京举行的2008年国家统计局年会上公布。我们需要积累样本来分析SNP与OAB严重程度的相关性。尿路上皮分泌的PGE2响应膀胱扩张刺激c - 5传入神经,随后促进逼尿肌过度活动。这种机制在BOO患者中似乎是正确的。然而,PGE2水平与脑血管意外患者OAB的严重程度相关。它们并没有被证实存在。这些结果表明可能存在其他潜在的机制来解释PGE2在OAB中的作用。少
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Effects of antimuscarinics on voiding function after cerebral infarction in a rat model of overactive bladder.
抗毒蕈碱药对膀胱过度活动症大鼠脑梗死后排尿功能的影响。
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Yusup A;Akino H;Miwa Y;Oyama N Aoki Y;Ito H;Tanase K;Matsuta Y;Nakai M;Yokoyama O.
- 通讯作者:Yokoyama O.
Improvement of bladder storage function by tamusulosin depends on suppression of C-fiber urethral afferent activity in rats.
坦莫罗辛对膀胱储存功能的改善取决于对大鼠尿道 C 纤维传入活动的抑制。
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Yokoyama O;Yusup A;Oyama N;Aoki Y;Miwa Y;Akino H
- 通讯作者:Akino H
Identification of alpha-1L and alpha-1A adrenoceptors in human prostate by tissue segment binding
通过组织片段结合鉴定人前列腺中的 α-1L 和 α-1A 肾上腺素受体
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Morishima S;Tanaka T;Yamamoto H;Suzuki F;Akino H;Yokoyama O;Muramatsu I
- 通讯作者:Muramatsu I
Improvement of bladder storage function by alphal-blocker depends on the suppression of C-fiber afferent activity in rats.
α-受体阻滞剂对膀胱储存功能的改善取决于对大鼠 C 纤维传入活动的抑制。
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Yokoyama O;Yusup A;Oyama N;Aoki Y;Tanase K;Matsuta Y;Miwa Y;Akino H
- 通讯作者:Akino H
Improvement in bladder storage function by tamsulosin depends on suppression of C-fiber urethral afferent activity in rats
- DOI:10.1016/j.juro.2006.09.076
- 发表时间:2007-02-01
- 期刊:
- 影响因子:6.6
- 作者:Yokoyama, Osamu;Yusup, Anwar;Akino, Hironobu
- 通讯作者:Akino, Hironobu
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YOKOYAMA Osamu其他文献
YOKOYAMA Osamu的其他文献
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{{ truncateString('YOKOYAMA Osamu', 18)}}的其他基金
Interdisciplinary study of neural circuit mechanisms of spatial attention
空间注意神经回路机制的跨学科研究
- 批准号:
15K16016 - 财政年份:2015
- 资助金额:
$ 10.77万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Roles of prefrontal cortex and basal ganglia in decision making based on preference
前额叶皮层和基底神经节在基于偏好的决策中的作用
- 批准号:
23700504 - 财政年份:2011
- 资助金额:
$ 10.77万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Does prevention of metabolic syndrome lead to improvement of erectile dysfunction or lower urinary tract symptoms?
预防代谢综合征是否可以改善勃起功能障碍或下尿路症状?
- 批准号:
21659370 - 财政年份:2009
- 资助金额:
$ 10.77万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Does polymorphism of metabolic syndrome-related genes induce lower urinary tract symptoms?
代谢综合征相关基因多态性是否会诱发下尿路症状?
- 批准号:
20390422 - 财政年份:2008
- 资助金额:
$ 10.77万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Identification and suppression of specific genes of urinary incontinence using RNAi
利用 RNAi 识别和抑制尿失禁的特定基因
- 批准号:
16390461 - 财政年份:2004
- 资助金额:
$ 10.77万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Functional analysis of specific genes of urinary incontinence in the pontine micturition center
脑桥排尿中枢尿失禁特异性基因的功能分析
- 批准号:
14370507 - 财政年份:2002
- 资助金额:
$ 10.77万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Signal transdaction and gene expression in the pors associated with the overactive bladder following cerebra-vascular disease
脑血管疾病后膀胱过度活动症相关的信号转导和基因表达
- 批准号:
12470331 - 财政年份:2000
- 资助金额:
$ 10.77万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Central muscarinic mechanisms of bladder overactivity associated with Alzheimer type senile dementia.
与阿尔茨海默型老年痴呆相关的膀胱过度活动的中枢毒蕈碱机制。
- 批准号:
10470334 - 财政年份:1998
- 资助金额:
$ 10.77万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
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