Does prevention of metabolic syndrome lead to improvement of erectile dysfunction or lower urinary tract symptoms?

我们调查了代谢综合征的预防是否导致勃起功能障碍和下尿路功能障碍的改善。作为代谢综合征的动物模型，我们使用OLETF（Otsuka-Evans德岛肥胖）大鼠和Dahl盐敏感（DS）大鼠，研究下尿路功能.雄性OLETF大鼠的平均体重从24周龄到40周龄显著增加，但从64周龄开始显著下降。收缩压从24周龄开始逐渐升高。在24周龄和56周龄时，OLETF大鼠的血浆甘油三酯、胆固醇、胰岛素和葡萄糖均显著高于LETO大鼠。这些特点提示OLETF大鼠可作为评价代谢综合征与LUTS关系的模型. OLETF大鼠从24周龄开始24小时的排尿频率显著增加，从56岁开始平均排尿量显著增加 关于我们 周这说明雄性OLETF大鼠从早期到晚期都具有尿频、多尿的排尿特征.膀胱测压显示，OLETF大鼠在24周龄时出现非排尿性收缩（NVCs），56周龄时明显增加。56周龄时膀胱重量、最大膀胱容量和残余尿量显著增加. 20 cm H2O压力牵张的OLETF大鼠膀胱释放ATP、PGE 2和NGF的量分别显著增加3。87±0。46，2。80±0。34，1. 37±0。是LETO大鼠的22倍。8-OHdG在OLETF大鼠膀胱中的含量为4。71±0。比LETO大鼠高68倍。在Dahl盐敏感大鼠（DS）中，交感神经活动随着盐负荷而增强，但在Dahl盐耐受大鼠（DR）中则没有。6周龄雄性DS和DR喂食正常（0.高盐饮食（8%）和饮水（40 ml/d）治疗12周。在非麻醉状态下通过尾动脉测量血压。在代谢笼中全天记录尿量和频率。我们计算了非活动期（睡眠）尿量指数（IUi），其定义为非活动期的尿量除以24小时尿量。盐负荷2周后，DS的收缩压和舒张压升高20 ~ 30 mmHg。盐负荷增加了DS和DR在活动期（清醒期）的尿量，在非活动期，正常或高盐饮食的DR的平均排尿量逐渐增加，而高盐饮食的DS无变化。10周盐负荷后，DR组和DS组的平均排尿量有显著差异。高盐饮食的DS在盐负荷后2周IUi升高，4周内维持在正常范围。少

We investigated whether the prevention of metabolic syndrome led to improvement of erectile dysfunction and lower urinary tract dysfunction. As animal models of metabolic syndrome, we used OLETF(Otsuka-Evans Tokushima Fatty) rats and Dahl salt-sensitive(DSs) rats, and investigated the function of the lower urinary tract.1. The average body weight of male OLETF rats was significantly increased from the age of 24 weeks to 40 weeks, but significantly decreased from the age of 64 weeks. The systolic blood pressure was gradually increased from the age of 24 weeks. Plasma triglyceride, cholesterol, insulin and glucose were significantly higher in OLETF rats than in LETO rats both at the age of 24 and 56 weeks. These characteristics suggest that OLETF rat could be a model in evaluating the relationship between MetS and LUTS.2. The urinary frequency for 24 h was significantly greater in OLETF rats from the age of 24 weeks, and the mean voided volume was significantly greater from the age of 56 … More weeks. This suggests that the male OLETF rats have micturition characteristics of frequent micturition and polyuria from early stage to late stage.3. On cystometry, non-voiding contractions(NVCs) was observed in OLETF rats at the age of 24 weeks, and markedly increased at the age of 56 weeks. The bladder weight, maximum bladder capacity and residual urine were significantly increased at the age of 56 weeks.4. The amount of ATP, PGE2 and NGF released from 20 cm H2O pressure-stretched bladder of OLETF rats was, respectively, significantly increased 3. 87±0. 46, 2. 80±0. 34, 1. 37±0. 22 times as much as those of LETO rats. The amount of 8-OHdG in the bladder of OLETF rats was 4. 71±0. 68 times higher than that of LETO rats.5. The sympathetic nerve activity is augmented with salt loading in Dahl salt-sensitive rats(DSs), but not in Dahl salt-resistant rats(DRs). Six-week-old male DSs and DRs were fed with a normal(0. 3%) or high-(8%) salt diet and 40ml water/day for 12 weeks. Blood pressure was measured through the tail artery under non-anesthetizing state. Urine volume and frequency were recorded all day long in metabolic cage. We calculated inactive period(sleeping) urine volume index(IUi), which was defined as urine volume during inactive period divided by 24-h urine output. Twenty to 30 mmHg increase in systolic and diastolic blood pressure was noted in DSs after 2 week-salt loading. Salt loading increased urine production during active(awake) period of the day both in DSs and DRs. In inactive period, mean voided volume gradually increased in DRs fed with normal or high salt diet, while did not change in DSs fed with high-salt diet. There were significant differences in mean voided volume after 10 week-salt loading between DRs and DSs fed with high-salt diet. In DSs fed with high-salt diet, IUi increased 2 weeks after salt loading, and remained normal range within 4 weeks. Less