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An investigation on the neural network for impaired articulation using non-invasive functional brain imaging

使用非侵入性功能性脑成像对关节受损的神经网络进行研究

基本信息

批准号：
18390553
负责人：
ONO Takashi
金额：
$ 10.46万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390553/
关键词：
impaired speech covert speech overt speech cleft lip and palate velar plosive fMRI central nervous system 脳賦活代償性構音構音点破裂音脳賦活パタン小脳

项目摘要

Neural networks for speech may be subdivided into two stages, such as the imaginary and executive stages, and products from these stages are called covert and overt speech, respectively. On the other hand, subjects with cleft lip and palate (CLP) axe known to show impaired speech, or compensatory misarticulation. Previous studies showed that these were significant differences between subjects with and without CLP in 1) the activated pattern in the brain during articulation (Shinagawa, et al., 2006), and 2) the movement pattern of the articulators (Sato-Wakabayashi, et al., 2008). However, the responsible stage for the difference in articulation between those with and without CLP was unknown. Adult subjects with [unilateral (UCLP) and bilateral (BCLP)l and without CLP were recruited. We used a 1.5 T MR apparatus. Functional MRI data were taken while the subject repeated the velar plosive, /ka/, at 1.5 Hz for either covert (C) or overt (O) speech in the block design SPM2 was used for analysis. It was shown that the premotor area was activated during C speech in subjects with and without CLP. During O speech, the premotor area, the primary motor cortex and the cerebellum were activated in subjects with UCLP and those without CLP,. On the other hand, these areas were not activated but the posterior cingulate gyrus was activated in the subject with BCLP. These findings suggest that there seems to be little difference in the imaginary stage, but there are differences in the executive stage for articulation between subjects with and without CLP. It appears that several factors including types of the cleft, the difference in the motor outputs and sensory inputs, the types and severity of misarticulation and the timing and effect of speech therapy maybe involved in the difference.

用于语音的神经网络可以被细分为两个阶段，例如想象和执行阶段，并且来自这些阶段的产品分别被称为隐蔽语音和公开语音。另一方面，患有唇腭裂（CLP）的受试者已知表现出言语受损或代偿性发音错误。先前的研究表明，在患有和不患有CLP的受试者之间存在以下显著差异：1）在发音期间大脑中的激活模式（品川等人，2006），和2）关节的运动模式（Sato-Wakabayashi等人，2008年）。然而，负责阶段的差异之间的清晰度与无CLP是未知的。招募患有[单侧（UCLP）和双侧（BCLP）]和没有CLP的成人受试者。采用1.5T磁共振仪。当受试者以1.5 Hz重复软腭爆破音/ka/时，以区组设计进行隐性（C）或显性（O）语音的功能MRI数据，SPM 2用于分析。结果表明，运动前区被激活的C语言在受试者与无CLP。在O言语过程中，UCLP和非CLP受试者的运动前区、初级运动皮层和小脑被激活。另一方面，这些地区没有被激活，但后扣带回被激活的主题与BCLP。这些结果表明，似乎有一个小的差异，在想象阶段，但有差异的执行阶段之间的衔接与非CLP的主题。这种差异可能与腭裂类型、运动输出和感觉输入的差异、构音错误的类型和严重程度以及言语治疗的时机和效果等因素有关。