Investigation of the mechanisms of generation, impairment and plasticity of speech in cleft lip and palate

本研究旨在阐明语音的生物学背景，探讨唇腭裂语音的发生、损伤和可塑性的机制。结果表明：1)新研制的磁共振成像(MRI)电影用于研究发声的外周机制，2)外周关节运动(由MRI电影获得)与脑激活模式(由fMRI获得)之间存在显著的交互作用，3)舌觉对皮层的激活模式取决于咀嚼侧的偏好，4)健康受试者对声门停止知觉的听觉联结区的脑激活模式与正常发音不同。

The overall goal of this study was to elucidate the biological background of speech, and this study was aimed to investigate the mechanisms of generation, impairment and plasticity of speech in cleft lip and palate. Following results were obtained ; 1) Magnetic resonance imaging(MRI) movie was newly developed to investigate the peripheral mechanism for articulation, 2) significant interactions between peripheral articulatory movement(obtained using MRI movie) and brain activation pattern(obtained using fMRI) were found, 3) the cortical activation pattern by tongue sensation was dependent on the side preference of mastication, 4) brain activation pattern in auditory association area for glottal-stop perception was different from normal articulation in healthy subjects.