Investigation of the mechanisms of generation, impairment and plasticity of speech in cleft lip and palate

唇腭裂言语产生、损伤和可塑性机制的研究

• 批准号: 20390521
• 负责人: ONO Takashi
• 金额: $ 12.23万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390521/
• 关键词: 口唇口蓋裂; 構音; 中枢; 末梢; 磁気共鳴画像法; 口蓋裂言語; fMRI; 代償性構音; 聴覚連合野; 音声言語; MRI動画法; 構音障害; 破裂音; MRI movie; 重心; 内言語; 外言語; 脳賦活

The overall goal of this study was to elucidate the biological background of speech, and this study was aimed to investigate the mechanisms of generation, impairment and plasticity of speech in cleft lip and palate. Following results were obtained ; 1) Magnetic resonance imaging(MRI) movie was newly developed to investigate the peripheral mechanism for articulation, 2) significant interactions between peripheral articulatory movement(obtained using MRI movie) and brain activation pattern(obtained using fMRI) were found, 3) the cortical activation pattern by tongue sensation was dependent on the side preference of mastication, 4) brain activation pattern in auditory association area for glottal-stop perception was different from normal articulation in healthy subjects.

本研究的总体目标是阐明语音的生物学背景，并探讨唇腭裂患者语音的产生、损伤和可塑性机制。获得了以下结果：1）磁共振成像（MRI）电影是研究发音外周机制的最新发展，2）外周发音运动之间的重要相互作用（使用MRI电影获得）和大脑激活模式（3）舌感觉皮层激活模式依赖于咀嚼的偏侧偏好，（4）正常人声门-塞音知觉听觉联合区的激活模式与正常发音不同。

项目成果

Application of MRI movie for observation of articulatory movement during africative /s/ and a plosive /t/ : Tooth visualization in MRI.

应用 MRI 电影观察非洲音 /s/ 和爆破音 /t/ 期间的关节运动：MRI 中的牙齿可视化。

• 发表时间: 2011
• 期刊: Angle Orthod
• 影响因子: 3.4
• 作者: Ng IW;Ono T;et al.
• 通讯作者: et al.

Short-term changes in temporomandibular joint function in subjects with cleft lip and palate treated with maxillary distraction osteogenesis

上颌牵引成骨治疗唇腭裂患者颞下颌关节功能的短期变化

• 发表时间: 2008
• 期刊: Orthod Craniofac Res. 11(2)
• 作者: Hashimoto K;Otsuka R;Minato A;Sato-Wakabayashi M;Takada J;Inoue-Arai MS;Miyamoto JJ;Ono T;Ohyama K;Moriyama K.
• 通讯作者: Moriyama K.

咬合異常からみた舌機能の意義

从咬合异常角度看舌功能的意义

• 发表时间: 2010
• 期刊: 口病誌 77
• 作者: 松原良太;川野真太郎;清末崇裕;後藤雄一;中尾 祐;豊嶋健史;梯 裕恵;吉賀大午;北村亮二;大部一成;中村誠司;小野卓史
• 通讯作者: 小野卓史

「咬合機能矯正」へ向けての基礎的・臨床的アプローチ.東京矯正歯科学会

“咬合功能矫正”的基础和临床方法。

• 发表时间: 2011
• 作者: 鈴木尋之;須田直人;井関祥子;森山啓司;小野卓史
• 通讯作者: 小野卓史

Dilemma in skeletal Class III treatment : functional considerations from respiratory perspectives.

骨骼III类治疗的困境：从呼吸角度考虑功能。

• 发表时间: 2011
• 作者: Okuhara S.;Sagai T.;Shiroishi T.;Iseki S.;Ono T
• 通讯作者: Ono T