Investigation of the mechanisms of generation, impairment and plasticity of speech in cleft lip and palate

本研究的总体目标是阐明语音的生物学背景，并探讨唇腭裂患者语音的产生、损伤和可塑性机制。获得了以下结果：1）磁共振成像（MRI）电影是研究发音外周机制的最新发展，2）外周发音运动之间的重要相互作用（使用MRI电影获得）和大脑激活模式（3）舌感觉皮层激活模式依赖于咀嚼的偏侧偏好，（4）正常人声门-塞音知觉听觉联合区的激活模式与正常发音不同。

The overall goal of this study was to elucidate the biological background of speech, and this study was aimed to investigate the mechanisms of generation, impairment and plasticity of speech in cleft lip and palate. Following results were obtained ; 1) Magnetic resonance imaging(MRI) movie was newly developed to investigate the peripheral mechanism for articulation, 2) significant interactions between peripheral articulatory movement(obtained using MRI movie) and brain activation pattern(obtained using fMRI) were found, 3) the cortical activation pattern by tongue sensation was dependent on the side preference of mastication, 4) brain activation pattern in auditory association area for glottal-stop perception was different from normal articulation in healthy subjects.