Micrometastases of the Sentinel Lymph Node in the Patients with Lung Cancer

肺癌患者前哨淋巴结微转移

• 批准号: 21791313
• 负责人: ONO Takashi
• 金额: $ 2.91万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791313/
• 关键词: 肺癌; センチネルリンパ節; リンパ節郭清; 微小転移; 肺がん; リンパ節転移

Fifty one patients with clinical T1N0M0 non-small cell lung cancer (NSCLC) were enrolled in this study. Sentinel nodes (SNs) were then detected intraoperatively. After SN mapping, lobectomy and hilar and mediastinal lymph node dissection were performed. Metastases of all dissected lymph nodes were examined by hematoxylin and eosin (H&E) staining and immunohistochemical cytokeratin staining. SN detection rate was 80.4% (41/51). Average number of SNs was 1.8±1.1 in a patient. Lymph node metastases were diagnosed in two patients using H&E staining. LNMM were found only in SNs of two patients. On the other hand, micrometastasis was not found in non-SN. According to these results two patients with clinical T1N0M0 NSCLC migrated to T1N1M0. Evaluation of micrometastases of all dissected lymph nodes may be substituted by evaluating micrometastases of SNs.

51例临床T1N0M0非小细胞肺癌（NSCLC）患者入组本研究。然后在术中检测前哨淋巴结（SN）。SN标测后行肺叶切除、肺门及纵隔淋巴结清扫。所有切除的淋巴结转移灶均行苏木精-伊红（H & E）染色和免疫组化细胞角蛋白染色。SN检出率为80.4%（41/51）。每例患者的SN平均数为1.8 ± 1.1。使用H & E染色在两名患者中诊断出淋巴结转移。LNMM仅见于2例患者的SN。而非SN组未见微转移。根据这些结果，2例临床T1N0M0 NSCLC患者迁移至T1N1M0。所有清扫淋巴结的微转移的评价可以由评价SN的微转移代替。

项目成果

Sentinel node mapping and micrometastasis in patients with clinical stage IA non-small cell lung cancer.

• DOI: 10.1510/icvts.2009.214197
• 发表时间: 2009-10-01
• 期刊: Interactive cardiovascular and thoracic surgery
• 作者: Ono, Takashi;Minamiya, Yoshihiro;Ogawa, Junichi
• 通讯作者: Ogawa, Junichi

臨床病期IA期非小細胞肺癌におけるセンチネルリンパ節同定と微小転移

临床IA期非小细胞肺癌前哨淋巴结识别及微转移

• 发表时间: 2009
• 作者: Wada H;Yoshida S;Suzuki H;Sakairi Y;Yoshino I.;小野貴史
• 通讯作者: 小野貴史