Regional spinal card blood flow in rat with chronic spinal cord compression. The effect of laminectomy.

慢性脊髓受压大鼠的局部脊髓卡血流。

• 批准号: 18591604
• 负责人: OGINO Masahiro
• 金额: $ 2.43万
• 依托单位: Dokkyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591604/
• 关键词: myelopathy; animal experiment; rat; chronic spinal cord compression; spinal cord blood flow; 脳・神経; 脳神経疾患; 脊椎症性脊髄症; 血流量; 手術

The study compared two groups of rata one group of rats with chronic spinal card compression at C5-6 level and another group without spinal card compression. At the time of sacrifice three months after initial surgery, comparison of the body weight of the rats in the two groups did not exhibit statistically significant difference at the 5 % level. The weight of the spinal cord segments C3-4, C5-6, and C7-Th1 were compared. The compressed spinal cord (C5-6) weighed less than the counterpart in non-spinal-cord compression-rats, but the difference did not reach statistic significance at the 5 % level.The regional spinal cord blood flow at the C5-6 level was lower than the spinal cord blood flow at C3-4 level in chronically spinal-cord-compressed rat, were as the difference was not observed in rats without spinal cord compression. The comparison of the regional spinal card blood flow at C5-6 level between chronically spinal-cord-compressed rats and no compression rats did not show statistically significant difference.The ratio of regional spinal read blood flow at the C5-6 level to C3-4 level was determined for each rat There was a statistically significant difference at the 5 %level between the spinal-cord-compressed rats and non-compressed rats in the ratio of spinal blood flow C3-4 to C5-6.The effect of laminectomy on the spinal cord blood flow is to be determined in the fixture.The finding of this study showed decreased spinal cord blood flow in the compressed portion of the chronically compressed spinal ord. The significance of this finding is that this point to the possibility of the systemic conditions that may affect spinal and circulation affecting the outcome of spondylotic myelopathy, and there may be pharmacological treatment for the illness by improvement of spinal cord blood flow.

本研究比较了两组大鼠，一组C5-6水平有慢性脊髓卡压迫，另一组没有脊髓卡压迫。初始手术后3个月牺牲时，两组大鼠体重在5%水平下比较，差异无统计学意义。比较脊髓节段C3-4、C5-6和C7-Th1的重量。受压脊髓（C5-6）重量小于非受压脊髓大鼠，但在5%水平下差异无统计学意义。慢性脊髓受压大鼠C5-6水平的脊髓局部血流量低于C3-4水平的脊髓血流量，而非脊髓受压大鼠无此差异。慢性脊髓受压大鼠与无脊髓受压大鼠C5-6水平区域脊髓血流比较，差异无统计学意义。测定每只大鼠C5-6水平与C3-4水平的脊髓区域血流量之比。在5%水平下，脊髓受压大鼠与未受压大鼠的脊髓血流量C3-4与C5-6之比有统计学意义。椎板切除术对脊髓血流的影响将在固定装置中确定。本研究发现慢性脊髓受压受压部分的脊髓血流量减少，这一发现的意义在于提示可能影响脊柱和循环的全身性疾病影响脊髓型颈椎病的预后，可能存在通过改善脊髓血流量的药物治疗方法。

项目成果

Regional spinal cord blood flow in rat chronic spinal cord compression

大鼠慢性脊髓受压时的局部脊髓血流

• 发表时间: 2008
• 作者: Ryu;Kurokawa;Pho;Kim;Hidetoshi;Murata;Toshiki;Kawamoto;Masahiro;Ogino;Tetsuro;Shingo;Kazushige;Itoki
• 通讯作者: Itoki

慢性脊髄圧迫ラットにおける脊髄局所血流

慢性脊髓受压大鼠的局部脊髓血流

• 发表时间: 2008
• 期刊: 脊髄外科 22(2)
• 作者: 黒川龍;金彪;村田英俊;川本俊樹;荻野雅弘;新郷哲郎;糸岐一茂
• 通讯作者: 糸岐一茂