Changes of developments of central auditory system following early hearing loss in animal experiment.
Changes of developments of central auditory system following early hearing loss in animal experiment.
批准号:
22591877
负责人:
ITO Makoto
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
本研究的目的是探讨早期听力损失对中枢听觉系统的解剖,特别是对下丘的上行投射的影响。我们将正常动物与在发育早期使用阿米卡星致聋的动物进行了比较,阿米卡星是一种耳毒性抗生素,已知会破坏内耳的毛细胞。新生儿耳聋减少了从CN投射到IC的标记神经元的数量,这种影响在耳聋的后期阶段更加明显。相比之下,从DNLL到IC的投射没有显著变化。
英文摘要
The purpose of this study was to investigate the effects of early hearing loss on the anatomy of the central auditory system, specifically, the ascending projections to the inferior colliculus (IC). We compared normal animals with animals deafened during early development by administration of amikacin, an ototoxic antibiotic that is known to destroy the hair cells in the inner ear. Neonatal deafness reduces the number of labeled neurons projecting from the CN to the IC with the effect being more evident during later stages of deafness. In contrast, there are no significant changes in the projections from DNLL to IC.
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DOI:
10.1016/j.anl.2011.10.009
发表时间:
2012-12-01
期刊:
AURIS NASUS LARYNX
影响因子:
1.7
作者:
[Sugimoto, Hisashi, Ito, Makoto, Yoshizaki, Tomokazu]
通讯作者:
Yoshizaki, Tomokazu
DOI:
10.1016/j.heares.2012.03.011
发表时间:
2012-05
期刊:
Hearing Research
影响因子:
2.8
作者:
[M. Hatano;Makoto Ito;T. Yoshizaki;J. Kelly]
通讯作者:
M. Hatano;Makoto Ito;T. Yoshizaki;J. Kelly
Serotype Distribution and Penicillin Resistance of Streptococcus pneumoniae Isolates from Nasopharynx in Young Children Attending Day Care in Japan
日本日托幼儿鼻咽分离肺炎链球菌的血清型分布和青霉素耐药性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ito M, Hatano M, Sugimoto H, Yoshizaki T]
通讯作者:
Yoshizaki T
DOI:
--
发表时间:
2010
期刊:
Auris Nasus Larynx (In press)
影响因子:
--
作者:
[Sugimoto H, Ito M, Hatano M, Nakanishi Y, Maruyama Y, Yoshizaki T.]
通讯作者:
Yoshizaki T.
DOI:
10.1097/mao.0b013e31820d9654
发表时间:
2011-04
期刊:
Otology & Neurotology
影响因子:
2.1
作者:
[H. Sugimoto;Makoto Ito;M. Hatano;S. Kondo;Shioto Suzuki;T. Yoshizaki]
通讯作者:
H. Sugimoto;Makoto Ito;M. Hatano;S. Kondo;Shioto Suzuki;T. Yoshizaki
共 11 条
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Unified studies of molecular structures and reaction mechanism In light neutron-excess systems
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Paleohydrology in greenhouse and icehouse stages
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Sphingolipid Engineering Using Marine Resources
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The role of transcription factor ATBF1 for the expression of gastro intestinal phenotype in mucosal cells and gastro inestinal Cancer cells.
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EFFECTIVE ENFORCEMENT OF JUDGMENT DEBTS.
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Effects of three dimensional electrical properties on the mechanisms of initiation, maintenance, and termination of atrial fibrillation ; clinical and computer simulation study
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Comparative sedimentology between greenhouse and icehouse stratigraphic successions
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