权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The study of diet management, focused on oral supplement of L-arginine plus folic acid for prevention of . preeclampsia

饮食管理研究的重点是口服补充L-精氨酸加叶酸来预防。

基本信息

批准号：
18591807
负责人：
SUZUKI Yoshikatsu
金额：
$ 2.48万
依托单位：
Nagoya City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591807/
关键词：
preeclampsoia endothelial dysfunction folic acid L-arginine prevention

项目摘要

Preeclampsia, characterized as hypertension and proteinuria threatens to both maternal and fetal life. It causes to increase vascular tone and permeability due to the activation of endothelial function. There are two differ types of the disease. One is dependent on the placental disorder, which is caused by faulty of placentation at early pregnant time. The increases in production of cytokines and superoxide, and insulin resistance might be involved in the pathophysiology with and without placental disorder. Thus, it is important for the management of diet, including sodium and vitamin to treat and prevent it, being similar to metabolic syndrome. In the present study, we investigated whether or not an oral supplementation of L-arginine plus folic acid could improve endothelial dysfunction seen in preeclampsia.The concentration of serum L-arginine had been increasing advancing gestational ages, however it was reduced in preeclamptic women. Furthermore, flow mediate vasodilatation (FMD), non-invasive evaluation of endothelial function using ultrasound was reduced in both preeclamptic and high risk women (previous preeclampsia). In preeclamptic women, the reduction could not be improved by profuse supplementation of L-arginine 9g plus folic acid 5 mg / day for a several days. In high risk women, the reduction could be improved by the profuse supplement as well as contentious administration of L-arginine lg plus folic acid 0.8mg/day from the second trimester. In conclusion, the supplementation of L-arginine plus folic acid might prevent the endothelial dysfunction seen in preeclampsia.

子痫前期以高血压和蛋白尿为特征，严重威胁母儿生命。由于内皮功能的激活，它导致血管张力和渗透性增加。有两种不同类型的疾病。一种是依赖于胎盘疾病，这是由于在怀孕早期的胎盘缺陷引起的。细胞因子和超氧化物产生的增加以及胰岛素抵抗可能与有或无胎盘疾病的病理生理学有关。因此，重要的是管理饮食，包括钠和维生素，以治疗和预防它，类似于代谢综合征。在本研究中，我们调查了口服补充L-精氨酸加叶酸是否可以改善先兆子痫患者的内皮功能障碍。血清L-精氨酸浓度随着胎龄的增加而增加，但在先兆子痫患者中则降低。此外，在先兆子痫和高危女性（既往先兆子痫）中，血流介导的血管舒张（FMD）、使用超声对内皮功能的非侵入性评估都减少了。在先兆子痫的妇女中，连续几天大量补充L-精氨酸9 g+叶酸5 mg /天不能改善降低。在高危妇女中，从孕中期开始，大量补充L-精氨酸lg+叶酸0.8mg/天可以改善降低。总之，补充L-精氨酸加叶酸可以预防先兆子痫中的内皮功能障碍。