The study of diet management, focused on oral supplement of L-arginine plus folic acid for prevention of . preeclampsia

先兆子痫，特点是高血压和蛋白尿威胁到母亲和胎儿的生命。由于内皮功能的激活，使血管张力和通透性增加。这种疾病有两种不同的类型。一种是依赖于胎盘障碍，这是由于妊娠早期胎盘的缺陷引起的。细胞因子和超氧化物产生的增加以及胰岛素抵抗可能与胎盘紊乱的病理生理有关。因此，与代谢综合征类似，重要的是通过饮食管理，包括钠和维生素来治疗和预防它。在本研究中，我们研究了口服补充l -精氨酸加叶酸是否能改善子痫前期内皮功能障碍。血清l -精氨酸的浓度随着孕龄的增加而增加，但是在子痫前期的妇女中却降低了。此外，血流介导的血管舒张（FMD），超声对内皮功能的无创评估在子痫前期和高危女性（既往子痫前期）中都有所减少。在先兆子痫妇女中，这种减少不能通过大量补充l -精氨酸9g加叶酸5mg /天持续几天来改善。在高危妇女中，从妊娠中期开始，大量补充l -精氨酸lg和叶酸0.8mg/天，可以改善这种减少。综上所述，补充l -精氨酸加叶酸可预防子痫前期内皮功能障碍。

Preeclampsia, characterized as hypertension and proteinuria threatens to both maternal and fetal life. It causes to increase vascular tone and permeability due to the activation of endothelial function. There are two differ types of the disease. One is dependent on the placental disorder, which is caused by faulty of placentation at early pregnant time. The increases in production of cytokines and superoxide, and insulin resistance might be involved in the pathophysiology with and without placental disorder. Thus, it is important for the management of diet, including sodium and vitamin to treat and prevent it, being similar to metabolic syndrome. In the present study, we investigated whether or not an oral supplementation of L-arginine plus folic acid could improve endothelial dysfunction seen in preeclampsia.The concentration of serum L-arginine had been increasing advancing gestational ages, however it was reduced in preeclamptic women. Furthermore, flow mediate vasodilatation (FMD), non-invasive evaluation of endothelial function using ultrasound was reduced in both preeclamptic and high risk women (previous preeclampsia). In preeclamptic women, the reduction could not be improved by profuse supplementation of L-arginine 9g plus folic acid 5 mg / day for a several days. In high risk women, the reduction could be improved by the profuse supplement as well as contentious administration of L-arginine lg plus folic acid 0.8mg/day from the second trimester. In conclusion, the supplementation of L-arginine plus folic acid might prevent the endothelial dysfunction seen in preeclampsia.