The study of diet management, focused on oral supplement of L-arginine plus folic acid for prevention of . preeclampsia

以高血压和蛋白尿为特征的先兆子痫对母亲和胎儿的生命都构成威胁。由于内皮功能的激活，导致血管张力和通透性增加。这种疾病有两种不同的类型。一种是依赖于胎盘紊乱，这是由怀孕早期的胎盘缺陷引起的。细胞因子和超氧化物歧化酶的产生增加以及胰岛素抵抗可能参与了胎盘紊乱的病理生理过程。因此，重要的是饮食管理，包括钠和维生素，以治疗和预防它，类似代谢综合征。在本研究中，我们研究了口服L-精氨酸加叶酸是否可以改善先兆子痫患者的内皮功能障碍。血清L-精氨酸浓度随着胎龄的增加而增加，而在先兆子痫妇女中则降低。此外，血流介导性血管扩张(FMD)，即超声对内皮功能的非侵入性评估，在先兆子痫和高危妇女(既往先兆子痫)中都减少了。对于子痫前期妇女，补充L精氨酸9g加叶酸5 mg/d，连用数天并不能改善降压效果。在高危妇女中，从妊娠中期开始大量补充和有争议地服用L-精氨酸LG加叶酸0.8 mg/天，可以改善这种减少。综上所述，补充L精氨酸和叶酸可以预防子痫前期患者的内皮功能障碍。

Preeclampsia, characterized as hypertension and proteinuria threatens to both maternal and fetal life. It causes to increase vascular tone and permeability due to the activation of endothelial function. There are two differ types of the disease. One is dependent on the placental disorder, which is caused by faulty of placentation at early pregnant time. The increases in production of cytokines and superoxide, and insulin resistance might be involved in the pathophysiology with and without placental disorder. Thus, it is important for the management of diet, including sodium and vitamin to treat and prevent it, being similar to metabolic syndrome. In the present study, we investigated whether or not an oral supplementation of L-arginine plus folic acid could improve endothelial dysfunction seen in preeclampsia.The concentration of serum L-arginine had been increasing advancing gestational ages, however it was reduced in preeclamptic women. Furthermore, flow mediate vasodilatation (FMD), non-invasive evaluation of endothelial function using ultrasound was reduced in both preeclamptic and high risk women (previous preeclampsia). In preeclamptic women, the reduction could not be improved by profuse supplementation of L-arginine 9g plus folic acid 5 mg / day for a several days. In high risk women, the reduction could be improved by the profuse supplement as well as contentious administration of L-arginine lg plus folic acid 0.8mg/day from the second trimester. In conclusion, the supplementation of L-arginine plus folic acid might prevent the endothelial dysfunction seen in preeclampsia.