The study for the nutritional management of endothelial dysfunction seen in pregnancy-induced hypertension

点击翻译按钮获取中文摘要

Preeclampsia causes to increase vascular tone and permeability due to the activation of endothelial function. In the present study, we investigated whether an oral supplementation of L-arginine plus folic acid could improve it and prevent from developing preeclampsia. The concentration of L-arginine in RBC had been increasing in normal pregnant women, while it was reduced in preeclamptic women. Flow mediate vasodilatation (FMD), non-invasive evaluation of endothelial function using ultrasound was reduced in high risk women at early pregnancy. The reduction could be improved by the contentious administration of L-arginine 1g plus folic acid 0.8mg/day from the second trimester. In conclusion, the supplementation of L-arginine plus folic acid might improve the endothelial dysfunction seen in high risk group and prevent onset of preeclampsia.