Clinical management of characteristic changes of endothelial function in pregnancy induced hypertension

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The aim is to improve the endothelial cells dysfunction seen in pregnancy induced hypertension (PIH). The diagnosis of hypertension of PIH was established by home blood pressure measurement and 24 hour ambulatory blood pressure monitoring instead of clinic BP. Furthermore, endothelial cell function was evaluated by flow mediated vasodilatation (FMD) of brachial artery by hyperemia. Administration of L-arginine plus folic acids might improve reduced FMD in high risk women of PIH and prevent from PIH, especially preeclampsia. While oral administration of labetalol could stabilized BP in PIH, especially gestational hypertension, nicardipine iv. could inhibit severe hypertension in puerperal women complicated by hypertensive emergency.