Analysis of neural network generating laryngeal multifunctional activities

产生喉部多功能活动的神经网络分析

• 批准号: 18591859
• 负责人: NAKAZAWA Ken
• 金额: $ 2.48万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591859/
• 关键词: larynx; swallowing

The larynx serves various behaviors including vocalization, breathing and airway protection reflexes such as swallowing and conghing. To elucidate the neural mechanism generating laryngeal motor patterns during the behaviors, the membrane potential trajectories of expiratory (ELMs) and inspiratory (ILMs) laryngeal motoneurons were recorded during fictive breathing and swallowing in decerebrated and paralyzed cats. ELMs were hyperpolarized during the inspiratory phase of breathing and at the onset of the pharyngeal stage of swallowing, whereas ILMs were hyperpolarized during the post-inspiratory phase of breathing and during the whole pharyngeal stage of swallowing. Such hyperpolarized membrane potentials observed during the initial part of pharyngeal stage in ELMs and during the whole pharyngeal stage in ILMs were reversed by intracellular injection of chloride ions and depolarized by extracellular injection of GABA antagonist. These results suggest that chloride-dependent, GABAergic inhibitory inputs to ELMs and ILMs are involved in the temporal organization of the laryngeal motor sequence during the behaviors.

喉部负责各种行为，包括发声、呼吸和气道保护反射，如吞咽和咳嗽。为了阐明在行为过程中产生喉部运动模式的神经机制，我们记录了失智猫和瘫痪猫在呼吸和吞咽过程中，呼气和吸气喉部运动神经元的膜电位轨迹。elm在呼吸吸气期和咽部吞咽期开始时呈超极化，而ilm在呼吸吸气后期和整个咽部吞咽期呈超极化。在ELMs咽期初期和ILMs咽期整个过程中观察到的这种超极化膜电位通过细胞内注射氯离子逆转，并通过细胞外注射GABA拮抗剂去极化。这些结果表明，在行为过程中，对ELMs和ILMs的氯依赖，gaba能抑制输入参与了喉运动序列的时间组织。

项目成果

Property of inhibitory inputs to laryngeal motoneurons during breathing and swallowing

呼吸和吞咽过程中喉部运动神经元的抑制输入特性

• 发表时间: 2007
• 作者: 中澤 健;他
• 通讯作者: 他