Single Nucleotide Polymorphisms (SNPs) associated with teeth loss

点击翻译按钮获取中文摘要

The aim of this study was to detect the Single Nucleotide Polymor-phisms (SNPs) associated with teeth loss.The subjects were 243 people who have over 20 teeth with age of over 80 years old (Dentulous group), and 61 people who were edentulous with age of 36~68 years old (Edentulous group) in 2002~2008. DNAs were sampling by Buccal Swab method, and was extracted by QIAamp DNA Mini. The proportion of allele types on the seven kind of SNPs related to interleukin-1ss, mitochondria and NFκB2 detected by ASP (Allels Specific Primer)-PCR method. And then, the difference of their proportions between Dentulous group and Edentulous group were analyzed. Regarding interleukin-1ss and mitochondria, there was no difference on the proportion of allele types between Dentulous group and Edentulous group. However, regarding the SNP of rs2281583related to NFκB2, there was a significant difference on the proportion of allele types between Dentulous group and Edentulous group. Moreover, allele type in Edentulous group indicated for only GG type. These findings is reasonable, because NFκB2play an important role as adjusting factor in the inflammation.In conclusion, it was suggested that AA type or AG type on SNP of rs2281583 related to NFκB2 is a healthy genetic factor.