Research for the mechanisms of the top-down control of the pain and its vulnerability

疼痛及其脆弱性自上而下控制机制研究

• 批准号: 18613007
• 负责人: KITAMURA Yuri
• 金额: $ 2.63万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18613007/
• 关键词: pain; affection; NIRS; depression; 痛み(ペイン); 脳機能イメージング; PET; 分子イメージング; 抗うつ薬; スルピリド(sulpiride); 認知機能

Patients with chronic pain frequently suffer from affective disorders, such as depression. Numerous studies have shown a reciprocal relationship between chronic pain and affective disturbance. Each disorder makes patients more vulnerable to the other, although the mechanisms are still unclear. Hypothalamo-pituitary-adrenal axis function might play an important role on the transition from acute to chronic pain. Also personality factors may influence pain processing.We investigate the mechanisms of the vulnerability for chronic pain by using the neuroimaging method, for example, NIRS; near-infrared spectroscopy, PET scanning and the measurement of eye-movement. Also the institution of the pain clinic center in our hospital could make a go of this study. Further investigations might be needed to establish the evidence-based therapy for chronic pain as well, however, our results must be useful to determine the therapeutical procedure for the patients suffering from severe chronic pain.

慢性疼痛患者经常患有情感障碍，如抑郁症。许多研究表明，慢性疼痛和情感障碍之间存在相互关系。每种疾病都使患者更容易受到另一种疾病的影响，尽管其机制尚不清楚。下丘脑-垂体-肾上腺轴功能在急性疼痛向慢性疼痛转变过程中可能起重要作用。人格因素也可能影响疼痛的处理，我们通过神经影像学方法，如近红外光谱、PET扫描和眼动测量来研究慢性疼痛易感性的机制。我院疼痛诊疗中心的建立也为此项研究的开展提供了条件。慢性疼痛的循证治疗还需要进一步的研究，然而，我们的研究结果必须有助于确定严重慢性疼痛患者的治疗程序。

项目成果

Serotonin2C receptor mRNA editing in neuropathic pain model.

神经病理性疼痛模型中 5-羟色胺2C 受体 mRNA 编辑。

• 发表时间: 2007
• 期刊: Neuroscience Research 60(2)
• 作者: Aya Nakae;et. al.
• 通讯作者: et. al.

Detection of. 18F-D0PA signal in brainstem monoaminergic nuclei in schizophrenia.

检测.

• 发表时间: 2006
• 作者: 喜多村祐里;ほか
• 通讯作者: ほか

Optimized Voxel Based Morphometry of the MRI in Schizophrenia.

基于体素的优化精神分裂症 MRI 形态测量。

• 发表时间: 2006
• 作者: Yoshida-T;et al.
• 通讯作者: et al.

急性疼痛と慢性疼痛における精神健康度およびうつ状態と主観的疼痛強度との関連性.

急性疼痛和慢性疼痛中心理健康水平与抑郁状态及主观疼痛强度的关系。

• 发表时间: 2009
• 期刊: ペインクリニック 30(1)
• 作者: 河野美樹;他
• 通讯作者: 他

Slow repetitive transcranial magnetic stimulation changes oscillatory magnetoencephalographic activity in two patients with thalamic pain.

缓慢重复经颅磁刺激改变了两名丘脑疼痛患者的振荡脑磁图活动。

• 发表时间: 2007
• 期刊: International Congress Series 1300
• 作者: Kurimoto-R;et al.
• 通讯作者: et al.