A research for developmental disorders using the eye-movement measure and the brain functional near-infrared spectroscopy

使用眼动测量和脑功能近红外光谱研究发育障碍

• 批准号: 21610011
• 负责人: KITAMURA Yuri
• 金额: $ 3.08万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21610011/
• 关键词: 広汎性発達障害; 眼球運動計測; サッカード; 注意欠陥多動性障害; バイオマーカー; サッケード

In this study, we adopted a very simple behavioral paradigm in which subjects are asked to maintain their eyes on the central fixation point and to simply follow peripheral visual stimuli by rapid eye movements(saccades). It has been shown previously that ADHD have problems with visual fixation and visually guided saccades. Here, we examined whether interactions between fixation and saccades are regulated appropriately in ADHD. We took advantage of gap effect, in which saccade initiation is facilitated by disappearance of the central fixation point before appearance of a peripheral target. Consistent with the previous studies, we confirmed that (1) reaction times were longer in ADHD than typically developing children(TD), and (2) reaction times were decreased with ages in both ADHD and TD. Furthermore, we found that gap effects were attenuated in ADHD regardless of ages. Besides, there was no correlation between gap effects and ADHD-RS or CBCL, suggesting that gap effects might capture deficits that cannot be identified by qualitative behavioral evaluation. This attenuation of the gap effect could become an objective measurement to support diagnosis and treatment of ADHD quantitatively.

在这项研究中，我们采用了一个非常简单的行为范式，在这个范式中，受试者被要求将他们的眼睛保持在中央注视点上，并通过快速眼动(扫视)简单地跟随外围视觉刺激。此前已有研究表明，ADHD在视觉注视和视觉引导的眼跳方面存在问题。在这里，我们研究了注视和眼跳之间的相互作用在ADHD中是否受到适当的调节。我们利用了间隙效应，在这种效应中，在外围目标出现之前，中心凝视点的消失促进了眼跳的启动。与前人的研究一致，我们证实(1)ADHD儿童的反应时比一般发育儿童(TD)的反应时长，(2)ADHD和TD的反应时都随着年龄的增长而减少。此外，我们发现ADHD患者的GAP效应无论年龄大小都有所减弱。此外，GAP效应与ADHD-RS或CBCL之间没有相关性，这表明GAP效应可能捕获了定性行为评估无法识别的缺陷。这种GAP效应的衰减可以成为ADHD诊断和治疗的客观指标。

项目成果

Association study of the G72 gene with schizophrenia in a Japanese population: A multicenter study

• DOI: 10.1016/j.schres.2009.01.019
• 发表时间: 2009-04-01
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Ohi, Kazutaka;Hashimoto, Ryota;Takeda, Masatoshi
• 通讯作者: Takeda, Masatoshi

サッケード眼球運動計測を用いた小児ADHD患者の脳内基盤に関する検討

利用扫视眼动测量研究儿童多动症患者的脑基础

• 发表时间: 2010
• 作者: E.A.Rashed;H.Kudo;喜多村祐里
• 通讯作者: 喜多村祐里

ブロナンセリン100の報告「ブロナンセリンへの置換により反響言語の減少と服薬アドヒアランスの向上が得られ、社会復帰を遂げた一例」

关于布南色林 100 的报告：“用布南色林替代可减少回声语言并改善用药依从性，从而成功重新融入社会的案例。”

• 发表时间: 2009
• 作者: 工藤博幸;イサムラシド;喜多村祐里(分担執筆)
• 通讯作者: 喜多村祐里(分担執筆)

Statistical Quantification of Brain Shape Deformation with Homologous Brain Shape Modeling

通过同源脑形状建模对脑形状变形进行统计量化

• 发表时间: 2010
• 期刊: World Automation Congress
• 作者: K.Yamaguchi;S.Kobashi;K.Kuramoto;Y.Kitamura;I.Mohri;S.Imawaki;M.Taniike;Y.Hata
• 通讯作者: Y.Hata

Free placement trans-skull doppler system with 1.0 MHz array ultrasonis probe.

带 1.0 MHz 阵列超声探头的自由放置经颅多普勒系统。

• 发表时间: 2010
• 期刊: Proceedings of the 2010 IEEE International conference on Systems, Man and Cybernetics
• 作者: Nakamura-M;Kitamura-Y;Yanagida-T;Kobashi-S;Kuramoto-K;Hata-Y
• 通讯作者: Hata-Y