Neural circuit formation in the mouse olfactory system

在这个项目中，我们揭示了嗅觉地图形成的分子逻辑。嗅觉感觉神经元（OSNs）的轴突通过基于OSNs的解剖位置的背腹图案化和由cAMP信号调节的前-后图案化的组合被引导到嗅球中的近似位置，cAMP信号的水平由气味受体种类唯一地确定。研究还发现，气味信息分别由两个不同的回路处理;一个是硬连线的先天反应，另一个是基于记忆的学习行为。

In this project, we have revealed the molecular logics of olfactory map formation. Axons of olfactory sensory neurons (OSNs) are guided to approximate locations in the olfactory bulb by a combination of dorsal-ventral patterning, which is based on anatomical locations of OSNs, and anterior-posterior patterning, which is regulated by cAMP signals whose levels are uniquely determined by odorant receptor species. It was also found that odor information is separately processed by two distinct circuits; one is for hard-wired innate responses, and the other is for memory-based learned behaviors.