Neural circuit formation in the mouse olfactory system

小鼠嗅觉系统中神经回路的形成

• 批准号: 19002012
• 负责人: SAKANO Hitoshi
• 金额: $ 451.44万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Specially Promoted Research
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19002012/
• 关键词: 軸索末端; シナプス形成; 神経地図; 匂い情報処理; 神経回路形成; 嗅覚神経地図; 軸索投射; 嗅覚受容体; cAMP; Gタンパク; GPCR; Neuropilin 1; 嗅神経細胞; 軸索選別; 糸球形成; 神経回路; 軸索誘導分子; 先天的本能行動; 記憶に基づく学習行動; セマフォリン; ニューロピリン; 匂い受容; 糸球地図; 先天的忌避行動; 匂い地図; 嗅覚情報処理; 学習行動

In this project, we have revealed the molecular logics of olfactory map formation. Axons of olfactory sensory neurons (OSNs) are guided to approximate locations in the olfactory bulb by a combination of dorsal-ventral patterning, which is based on anatomical locations of OSNs, and anterior-posterior patterning, which is regulated by cAMP signals whose levels are uniquely determined by odorant receptor species. It was also found that odor information is separately processed by two distinct circuits; one is for hard-wired innate responses, and the other is for memory-based learned behaviors.

在这个项目中，我们揭示了嗅觉图形成的分子逻辑。嗅觉感觉神经元 (OSN) 的轴突通过背腹模式和前后模式的组合被引导到嗅球中的大致位置，背腹模式基于 OSN 的解剖位置，而前后模式则受 cAMP 信号调节，而 cAMP 信号的水平由气味受体种类唯一决定。研究还发现，气味信息是由两个不同的电路分别处理的。一种是针对硬连线的先天反应，另一种是针对基于记忆的习得行为。

项目成果

Odorant Receptor Gene Choice and Axonal Projection in the Mouse Olfactory System

• DOI: 10.1007/400_2008_3
• 发表时间: 2009-01-01
• 期刊: CHEMOSENSORY SYSTEMS IN MAMMALS, FISHES, AND INSECTS
• 作者: Imai, T.;Sakano, H.
• 通讯作者: Sakano, H.

Innate versus learned odour processing in the mouse olfactory bulb

• DOI: 10.1038/nature06281
• 发表时间: 2007-11-22
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Kobayakawa, Ko;Kobayakawa, Reiko;Sakano, Hitoshi
• 通讯作者: Sakano, Hitoshi

Topographic Mapping-The Olfactory System

• DOI: 10.1101/cshperspect.a001776
• 发表时间: 2010-08-01
• 期刊: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
• 影响因子: 7.2
• 作者: Imai, Takeshi;Sakano, Hitoshi;Vosshall, Leslie B.
• 通讯作者: Vosshall, Leslie B.

OR-derived neuronal firing and basal activities of OSNs differentially regulate glomerulus map formation.

OR 衍生的神经元放电和 OSN 的基础活动差异调节肾小球图的形成。

• 发表时间: 2010
• 作者: Kihara;Y.;Matsushita;T.;Kita;Y.;Uematsu;S.;Akira;S.;Kira;J.-i.;Ishii;S.;Shimizu;T.;Ai Nakashima
• 通讯作者: Ai Nakashima

Odor Perception in the Mouse Olfactory System.

小鼠嗅觉系统的气味感知。

• 发表时间: 2008
• 作者: Hikiji;H.;Takato;T.;Shimizu;T.;and Ishii;S;C. Toyoshima;Hitoshi Sakano
• 通讯作者: Hitoshi Sakano