Chemical Syntheses of Natural and Designed Molecules : Innovative Research on Their New Functions, Antibodies and Receptors

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We have developed a general method for the total syntheses of ciguatoxins. Practical total synthesis of ciguatoxins allowed us to use them for interdisciplinary researches, such as unveiling the gating mechanism of voltage sensitive sodium channels. Highly sensitive anti-CTXlB monoclonal antibodiy and immunoassay method were developed to detect major congeners of ciguatoxin. Some of the previously prepared antibodies were modified for treating the human ciguatera poisoning. Furthermore, designed pseudo-ciguatoxins were also synthesized as bio-probes for understanding the biological mechanisms. On the other hand, total syntheses of the extremely potent antitumor chromoprotein nine-membered enediyne antibiotics and cortistatins were accomplished.