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Molecular mechanism for neuronal diversity and organization in the brain

Molecular mechanism for neuronal diversity and organization in the brain
大脑神经元多样性和组织的分子机制
批准号:
19100006
负责人:
YAGI Takeshi
金额:
$72.63万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2012

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中文摘要
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英文摘要
To examine molecular mechanism for generating neuronal diversity and for building neural network formation in the brain, we focused to diverse CNR/protocadherin molecules which express in the brain. In this study, we identified the several cis-elements, and revealed that DNA methylation and CTCF are essential to regulate expression of CNR/protocadherin genes in each neuron. And also we demonstrated that CNR/protocadherin- α molecules are essential to correct neural networkformation in the brain.
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DOI: 10.3389/fnmol.2012.00090
发表时间: 2012
期刊: Frontiers in molecular neuroscience
影响因子: 4.8
作者: [Hirano K, Kaneko R, Izawa T, Kawaguchi M, Kitsukawa T, Yagi T]
通讯作者: Yagi T
Neuronal diversity by clustered protocadherin genes
簇状原钙粘蛋白基因的神经元多样性
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Omata Y, Iida M, Yajima I, Takeda K, Ohgami N, Masaru Hori H, Kato M., Takeshi Yagi]
通讯作者: Takeshi Yagi
Promoter DNA methyl at ion is dependent on gene cluster structure and reulates allocation of isoforms express ion in each Protocadherin cluster.
启动子 DNA 甲基化取决于基因簇结构并调节每个原钙粘蛋白簇中异构体表达的分配。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Horino, T., 豊田峻輔]
通讯作者: 豊田峻輔
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Lindauer, M.L., Wong, J., Iwakura, Y., Magun, B.E., 烏山一, 八木健]
通讯作者: 八木健
108
    Development of novel biodesign mice by epistasis
    • 批准号:
      17K19683
    • 项目类别:
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额:
      $4.16万
    • 财政年份:
      2017
    • 负责人:
      YAGI Takeshi
    • 依托单位:
    A life design model using mutator mice
    • 批准号:
      15K14368
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2015
    • 负责人:
      YAGI Takeshi
    • 依托单位:
    Novel animal model by using high germline mutation rate
    • 批准号:
      25640047
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2013
    • 负责人:
      YAGI Takeshi
    • 依托单位:
    Production of new design mice by accumulation of mutations
    • 批准号:
      23650234
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2011
    • 负责人:
      YAGI Takeshi
    • 依托单位:
    海外基金