Analyses for regulation of brain system by using CNR/protocadherin molecules
Analyses for regulation of brain system by using CNR/protocadherin molecules
批准号:
17024034
负责人:
YAGI Takeshi
金额:
$77.18万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
The brain is a complex system, and is composed of enormous number of neurons, which have individual activity. To understand mechanism of generation and regulation of the complex brain system, we try to examine molecular mechanisms for acquiring neuronal individuality and for generating neural networks in the brain. Here we revealed that about 50 members of CNR/protocadherin genes are differentially expressed in individual neurons, and their expressions are random and combinatorial in each neuron. Also molecules of CNR/protocadherin have significant function for generating correct neural networks during brain development.
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The protocadherin-a family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouce.
原钙粘蛋白家族参与小鼠嗅觉感觉神经元轴突合并成嗅球肾小球的过程。
DOI:
--
发表时间:
2008
期刊:
Molecular Cellular Neuroscience (in press)
影响因子:
--
作者:
[Hasegawa, S, et. al.]
通讯作者:
et. al.
Restoration of FcRgammalFyn signaling repairs central nervous system demyelination.
FcRgammalFyn 信号的恢复可修复中枢神经系统脱髓鞘。
DOI:
--
发表时间:
2007
期刊:
Journal of Neuroscience Research 85
影响因子:
--
作者:
[Seiwa, C, et. al.]
通讯作者:
et. al.
Plexin-A4 Mediates Axon-Repulsive Activities of Both Secreted and Transmembrane Semphorins and Play Roles in Nerve Fiber Guidance.
Plexin-A4 介导分泌型和跨膜型 Semphorins 的轴突排斥活性,并在神经纤维引导中发挥作用。
DOI:
--
发表时间:
2005
期刊:
J.Neurosci. 25(14)
影响因子:
--
作者:
[Hirabayashi M, Kato M, Ishikawa A, Kaneko R, Yagi T, Hochi S., Sudo F et al.]
通讯作者:
Sudo F et al.
内因的な突然変異率上昇マウス系統を用いた実験室内進化モデルの試み
使用内源突变率增加的小鼠品系尝试建立实验室进化模型
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[内村有邦, 日高裕子, 三浦郁夫, 若菜茂晴, 古澤満, 八木健]
通讯作者:
八木健
クラスター型プロトカドヘリンにおける選択的組み合わせ発現の制御基盤の解析
簇状原钙粘蛋白选择性组合表达的调控基础分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[横田慎一, 平山晃斉, 平林敬浩, 河村佳見, 金子涼輔, 八木健]
通讯作者:
八木健
共 117 条
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