Computational analysis of human proteins addressing the relationship between intrinsic disorder and alternative splicing

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For all human proteins encoded on the genome, we have succeeded to classify protein molecules into structured or intrinsically disordered (ID) regions using the method we developed in this project. As a result, we revealed the total fractions of ordered/disordered regions of human proteins at a first time. Analyzing locations of alternative splicing (AS) data along the protein sequence, we have also revealed that AS events occur in proportion to the fraction of ID regions of proteins.