Molecular basis of pathogenicity of classical swine fever virus -Mechanism of down regulation of innate immunity in the cells and pigs infected with classical swine fever virus-

为研究经典猪瘟病毒的分子基础，利用反向遗传构建的突变病毒，分析1型干扰素介导的先天免疫下调机制。测定了控制1型干扰素产生的N^<pro>蛋白的关键氨基酸，认为1型干扰素介导的先天免疫下调是猪瘟病毒对猪致病性的重要因素之一。

To assess the molecular basis of classical swine fever virus, the mechanism of down regulation of innate immunity mediated by type-1 interferon was analyzed using mutant viruses constructed by reverse genetics. Critical amino acids of N^<pro> protein for the control of type-1 interferon production were determined and it was concluded that the down regulation of innate immunity mediated by type-1 interferon was one of the important factors for the pathogenicity of classical swine fever virus in pigs.