Unique response of hippocampal zinc in recognition and stress and prevention of stress-induced neuropsychological diseases

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Long-term potentiation (LTP) is known as a cellular mechanism of memory formation. In the hippocampus, Zn^<2+> attenuates mossy fiber LTP, while potentiated CA1 LTP. On the other hand, the stressful environment changes synaptic plasticity and memory formation. When rats were subjected to acute stress, zinc homeostasis in the extracellular compartment was significantly changed in the hippocampus. This change may attenuate LTP in the hippocampus. The present study suggests that Zn^<2+> signaling modulates LTP in the hippocampus.