A novel mechanism of resistance to methylmercury toxicity in central nerves systems

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A novel mechanism of resistance to methylmercury (MeHg) toxicity in central nerve system has been examined using mice exposed to MeHg prenatally. As a preliminary examination, acute and chronic gene expression after MeHg exposure has been examined, and revealed that the altered genes were related to the functional categories of development, inflammation, and cell death. The next examination had performed by the combined exposures during prenatal and adulthood periods, and gene expression profiling had been examined.