A novel mechanism of resistance to methylmercury toxicity in central nerves systems

中枢神经系统抵抗甲基汞毒性的新机制

• 批准号: 19390159
• 负责人: NAKAI Kunihiko
• 金额: $ 9.82万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390159/
• 关键词: 環境保健; メチル水銀; 胎児期曝露; マイクロアレイ; 遺伝子発現; 急性毒性; ストレス応答; メチル水

A novel mechanism of resistance to methylmercury (MeHg) toxicity in central nerve system has been examined using mice exposed to MeHg prenatally. As a preliminary examination, acute and chronic gene expression after MeHg exposure has been examined, and revealed that the altered genes were related to the functional categories of development, inflammation, and cell death. The next examination had performed by the combined exposures during prenatal and adulthood periods, and gene expression profiling had been examined.

研究了一种新的抗甲基汞（MeHg）毒性的中枢神经系统机制。作为初步检查，我们检测了MeHg暴露后的急性和慢性基因表达，发现改变的基因与发育、炎症和细胞死亡的功能类别有关。下一次检查是在产前和成年期间进行的，并检查了基因表达谱。

项目成果

Effects of perinatal coexposure to methylmercury and polychlorinated biphenyls on neurobehavioral development in mice

围产期同时接触甲基汞和多氯联苯对小鼠神经行为发育的影响

• 发表时间: 2008
• 期刊: Archives of Toxicology 82(6)
• 作者: Sugawara N;Ohba T;Nakai K;Kakita A;Nakamura T;Suzuki K;Kameo S;Shimada M;Kurokawa N;Satoh C;Satoh H
• 通讯作者: Satoh H

Effects of perinatal exposure to methylmercury and/or polychlorinaled biphenyls on mouse neurobehavioral development and analysis of geneexpression in the brain.

围产期接触甲基汞和/或多氯联苯对小鼠神经行为发育和大脑基因表达分析的影响。

• 发表时间: 2007
• 期刊: Organohalogen Compounds 69
• 作者: Kameo S;et. al.
• 通讯作者: et. al.

Effects of perinatal exposure to methylmercury and/or polychlorinated biphenyls on mouse neurobehavioral development and analysis of gene expression in the brain

围产期接触甲基汞和/或多氯联苯对小鼠神经行为发育的影响和大脑基因表达分析

• 发表时间: 2007
• 期刊: Organohalogen Compounds 69
• 作者: Kameo S;Shimada M;Sugawara N;Murata-Mizukami S;Ohba T;Nakai K;Iwahashi;H;Satoh H
• 通讯作者: Satoh H

Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls

围产期暴露于甲基汞和/或多氯联苯的新生小鼠大脑中的基因表达谱

• 发表时间: 2010
• 期刊: Archives of Toxicology
• 影响因子: 6.1
• 作者: Shimada;M.;S. Kameo;N. Sugawara;K. Yaginuma-Sakurai;N. Kurokawa;S. Mizukami-Murata;K. Nakai;I. Hitoshi;H. Satoh
• 通讯作者: H. Satoh