Nested case-control study on the effects of prenatal exposure to PCBs

环境暴露于多氯联苯（PCBs）已被认为是儿童神经行为发育的危险因素。进行了一项巢式病例对照研究，以调查42个月时认知结果与产前暴露于PCB和DDE之间的关系。东北儿童发育研究队列包含在日本东部东北地区健康孕妇分娩时收集的脐带血样本。认知评分采用儿童考夫曼评估量表（K-ABC）进行评估。在调整了母亲的智商、母亲的年龄、妊娠期、母亲的鱼类摄入量、血浆omega-3/omega-6多不饱和脂肪酸等因素后，没有发现任何PCB和DDE与认知和同时加工得分有统计学意义的关联。

Environmental exposures to polychlorinated biphenyls (PCBs) have been suggested as a risk factor for neurobehavioral development in children. A nested case-control study was performed to investigate the association between the cognitive outcome at 42 months and the prenatal exposures to PCB and DDE. The Tohoku Study of Child Development cohort contains cord blood samples collected at the delivery of healthy pregnant women of the Tohoku district of east Japan. The cognitive score was assessed with the Kaufman Assessment Battery for Children (K-ABC). After adjusting with maternal IQ, maternal age, gestational days, maternal fish intake, plasma omega-3/omega-6 polyunsaturated fatty acids, and others, no statistically significant association with the cognitive and simultaneous processing scores was seen for any PCB and DDE.