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Prenatal and postnatal transfer of pesticides to children

产前和产后向儿童传播农药

基本信息

批准号：
14370118
负责人：
NAKAI Kunihiko
金额：
$ 8.83万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

Organochlorine pesticides are compounds widespread in the environment due to their persistence and highly lipophilic nature, and they accumulate in biological systems. Newborns are exposed to these organochlorine compounds across the placenta and through breastfeeding. In the present study, several organochlorine pesticides were analyzed in human breast milk and placenta from 20 mothers to identify the major pesticide compounds. This study was performed as part of our prospective cohort study. Healthy pregnant women were recruited with their informed consent at obstetrical wards of two hospitals in Tohoku between January 2001 and September 2003. The study protocol was approved by the Medical Ethics Committee of the Tohoku University Graduate School of Medicine. HCB, β-HCH, oxy-chlordane, cis-nonachlor, trans-nonachlor, p,p'-DOT, p,p'-DDE, dieldrin, and heptachlorepoxide were found from all breast milk samples and placenta samples. The relationship between pesticides in breast milk and the placenta was analyzed to examine the utilization of the placenta as the material for exposure assessment. The results showed that since there were excellent correlations of all major pesticides between breast milk samples and placenta samples, placenta was suggested to be the useful material to estimate the maternal body burden. In addition, the concentrations of some organochlorine pesticides ouch as HCB, oxy-chlordane, and trans-nonachlor, in the placenta samples had significant negative correlations with parity. This finding clearly shows that the mothers eliminate these pesticides during pregnancy and by breastfeeding into their children. The concentrations of oxy-chlordane, nonachlors, dieldrin, and heptachlorepoxide in breast milk samples and placenta samples were correlated with fish consumption ; however, HCB, HCH, and DDE had no association. These results indicated that the contribution of fish consumption to the intake of pesticides depended on the kind of pesticides.

有机氯农药因其持久性和高亲脂性而广泛存在于环境中，并在生物系统中积累。新生儿通过胎盘和母乳喂养接触这些有机氯化合物。在本研究中，对 20 名母亲的母乳和胎盘中的几种有机氯农药进行了分析，以确定主要农药化合物。这项研究是我们前瞻性队列研究的一部分。 2001年1月至2003年9月期间，在东北两家医院的产科病房招募了知情同意的健康孕妇。研究方案得到了东北大学医学研究生院医学伦理委员会的批准。所有母乳样本和胎盘样本中均发现了六氯苯、β-六氯环己烷、氯丹、顺式九氯、反式九氯、对,对'-DOT、对,对'-DDE、狄氏剂和环氧七氯。分析母乳中农药与胎盘之间的关系，以考察胎盘作为暴露评估材料的利用情况。结果表明，由于母乳样本和胎盘样本之间所有主要农药都具有良好的相关性，因此胎盘被认为是估计孕妇身体负担的有用材料。此外，胎盘样本中六氯苯、氯丹、反式九氯等有机氯农药的浓度与胎次呈显着负相关。这一发现清楚地表明，母亲在怀孕期间和通过母乳喂养孩子消除了这些农药。母乳样本和胎盘样本中的氯丹、九草胺、狄氏剂和七氯环氧化物的浓度与鱼类消耗量相关；然而，HCB、HCH 和 DDE 没有关联。这些结果表明，鱼类消费对农药摄入量的贡献取决于农药的种类。