A study of role of phospholipase A2 in pathogenosis of cardiovascular diseases and development of new drug for cardiovascular diseases

磷脂酶A2在心血管疾病发病中的作用研究及心血管疾病新药开发

• 批准号: 19390209
• 负责人: KUGIYAMA Kiyotaka
• 金额: $ 11.56万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390209/
• 关键词: 心筋梗塞; 心血管病; ノックアウトマウス; 分泌型ホスホリパーゼA; 炎症; 脂質メディエーター; 好中球

ホスホリパーゼA_2(PLA_2)を介して産生されるアラキドン酸カスケード関連脂質は心血管病の発症・病態に深く関与していることが示唆されている。本研究では、secretory PLA_2の心血管病への関与を網羅的に解明し、PLA_2を標的とする有用な心血管病予防・治療薬を開発することを目的とした。その結果、X型およびV型secretory PLA_2が心筋梗塞発生の病態に関与することが判明した。さらにsecretory PLA_2活性阻害剤が心不全を予防することを明らかにした。

The development and pathology of lipid related cardiovascular diseases are closely related to the formation of PLA_2 (PLA_2). This study aims to clarify the relationship between PLA_2 and cardiovascular disease, and to develop a useful method for the prevention and treatment of cardiovascular disease. The results showed that X-type and V-type secretarial PLA_2 were associated with the development of myocardial infarction. The secretary PLA_2 activity is blocked by the heart.

项目成果

Reduction in Myocardial Ischemia-reperfusion Injury in Group V Secretory Phospholipase A2-deficient Mice.

减少 V 组分泌性磷脂酶 A2 缺陷小鼠的心肌缺血再灌注损伤。

• 发表时间: 2009
• 作者: 竹本芳雄;et al;Toshiaki Yano; Keni-chi Kawabata; Yukio Saito; Tsuyoshi Kobayashi; Ryota Sato; Kazuhiro Watanabe; Yosuke Watanabe; Hideto Mishina; Jun-ei Obata; Kiyotaka Kugiyama
• 通讯作者: Toshiaki Yano; Keni-chi Kawabata; Yukio Saito; Tsuyoshi Kobayashi; Ryota Sato; Kazuhiro Watanabe; Yosuke Watanabe; Hideto Mishina; Jun-ei Obata; Kiyotaka Kugiyama

Rapid improvement of carotid plaque echogenicity within 1 month of pioglitazone treatment in patients with acute coronary syndrome

• DOI: 10.1016/j.atherosclerosis.2008.07.023
• 发表时间: 2009-04-01
• 期刊: ATHEROSCLEROSIS
• 影响因子: 5.3
• 作者: Hirano, Mitsumasa;Nakamura, Takamitsu;Kugiyama, Kiyotaka
• 通讯作者: Kugiyama, Kiyotaka

Reduction in Myocardial Ischemia-reperfusion Injury in Group IV Cytosolic Phospholipase A2-deficient Mice Partly Due to Inhibition of TNFα-mediated Pathway to Cell Injury.

IV 组胞质磷脂酶 A2 缺陷小鼠心肌缺血再灌注损伤的减少部分归因于抑制 TNFα 介导的细胞损伤途径。

• 发表时间: 2009
• 作者: Matsumoto;M.;ら;宮坂京子;Yukio Saito; Yousuke Watanabe; Hideto Mishina; Kazuhiro Watanabe; Toshiaki Yano; Tsuyoshi Kobayashi; Jun-ei Obata; Ken-ichi Kawabata; Takao Shimizu; Kiyotaka Kugiyama
• 通讯作者: Yukio Saito; Yousuke Watanabe; Hideto Mishina; Kazuhiro Watanabe; Toshiaki Yano; Tsuyoshi Kobayashi; Jun-ei Obata; Ken-ichi Kawabata; Takao Shimizu; Kiyotaka Kugiyama

Sirolimus-Eluting Stent implantation aggravates endothelial vasomotor dysfunction in the infarct-related coronary artery in patients with acute myocardial infarction

• DOI: 10.1016/j.jacc.2007.06.031
• 发表时间: 2007-10-02
• 期刊: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
• 影响因子: 24
• 作者: Obata, Iyun-ei;Kitta, Yoshinobu;Kugiyama, Kiyotaka
• 通讯作者: Kugiyama, Kiyotaka

Inhibition of secretory hospholipase A2 activity attenuates lipopolysaccharide-induced acute lung injury in a mouse model.

抑制分泌性磷脂酶 A2 活性可减轻小鼠模型中脂多糖诱导的急性肺损伤。

• 发表时间: 2010
• 期刊: Exp Lung Res. 36,4
• 作者: Sato R;Yamaga S;Watanabe K;Hishiyama S;Kawabata K;Kobayashi T;Fujioka D;Saito Y;Yano T;Watanabe K;Watanabe Y;Ishihara H;Kugiyama K.
• 通讯作者: Kugiyama K.