Clinical significance of remnant lipoproteinemia as a therapeutic target of cardiovascular diseases

残余脂蛋白血症作为心血管疾病治疗靶点的临床意义

基本信息

  • 批准号:
    15390244
  • 负责人:
  • 金额:
    $ 9.6万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2003
  • 资助国家:
    日本
  • 起止时间:
    2003 至 2005
  • 项目状态:
    已结题

项目摘要

This study aimed to determine whether elevated levels of remnant lipoprotein, an atherogenic triglyceride-rich lipoprotein, might be associated with coronary artery disease (CAD), endothelial vasomotor dysfunction, and future stroke in metabolic syndrome. The fasting serum levels of remnant lipoproteins (remnant-like lipoprotein particles cholesterol ; RLP-C) were measured by an immunoseparation method in 210 patients with metabolic syndrome meeting ATP III criteria. Flow-mediated endothelium-dependent dilatation (FMD) in the brachial artery during reactive hyperemia was examined by high-resolution ultrasound technique. This study found that elevated RLP-C levels were a significant and independent risk factor for impaired FMD and angiographically proven CAD. Kaplan-Meier analysis demonstrated that higher RLP-C levels resulted in a higher probability of ischemic stroke (P=0.02 by log-rank test). A multivariate Cox hazard analysis showed that high RLP-C levels were a significant predictor of a future ischemic stroke that was independent of components of the metabolic syndrome and other traditional atherosclerotic risk factors (odds ratio 3.2, 95% CI 1.2-8.1, P<0.01). Furthermore, high RLP-C levels were a significant risk of echolucent carotid plaques, assessed by carotid ultrasound with the integrated backscatter (IBS) analysis (intima-media IBS value minus adventitia IBS【less than or equal】-16 dB) that was independent of components of metabolic syndrome and other traditional atherosclerotic risk factors (odds ratio 4.3, 95% CI 1.6-6.7, P<0.01). Treatment with bezafibrate (n=20) or atorvastatin (n=20) for 4 weeks significantly reduced RLP-C levels, with a concomitant improvement in FMD. Thus, elevated levels of RLP-C are a risk factor for CAD, endothelial vasomotor dysfunction, a predictor of coronary events, and stroke in metabolic syndrome. Measurement of RLP-C is useful for assessment of risk of cardiovascular diseases and therapeutic effects in metabolic syndrome.
本研究旨在确定残余脂蛋白(一种致动脉粥样硬化的富含磷脂的脂蛋白)水平升高是否与代谢综合征患者的冠状动脉疾病(CAD)、内皮血管功能障碍和未来卒中相关。采用免疫分离法测定了210例符合ATP Ⅲ标准的代谢综合征患者空腹血清残余脂蛋白(残粒样脂蛋白颗粒胆固醇; RLP-C)水平。应用高分辨率超声技术检测反应性充血时肱动脉血流介导的内皮依赖性舒张功能(FMD)。这项研究发现,RLP-C水平升高是FMD受损和经血管造影证实的CAD的一个重要和独立的风险因素。Kaplan-Meier分析表明,RLP-C水平越高,缺血性卒中的概率越高(对数秩检验P=0.02)。多变量考克斯风险分析显示,高RLP-C水平是未来缺血性中风的重要预测因素,独立于代谢综合征和其他传统动脉粥样硬化危险因素的组成部分(优势比3.2,95%CI 1.2-8.1,P<0.01)。此外,高RLP-C水平是回声斑块的显著风险,通过颈动脉超声和背向散射积分(IBS)分析(内膜-中膜IBS值减去外膜IBS[小于或等于]-16 dB)进行评估,与代谢综合征和其他传统动脉粥样硬化风险因素的成分无关(比值比4.3,95% CI 1.6-6.7,P<0.01)。用苯扎贝特(n=20)或阿托伐他汀(n=20)治疗4周显著降低了RLP-C水平,同时改善了FMD。因此,RLP-C水平升高是代谢综合征中CAD、内皮血管功能障碍、冠状动脉事件和卒中的预测因子。RLP-C的测定有助于评估代谢综合征患者心血管疾病的危险性和治疗效果。

项目成果

期刊论文数量(21)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Prognostic value of remnant-like lipoprotein particles levels in patients with coronary artery disease and type 2 diabetes mellitus.
残余样脂蛋白颗粒水平对冠状动脉疾病和 2 型糖尿病患者的预后价值。
Remnant lipoproteinemia is a risk factor for endothelial vasomotor dysfunction and coronary artery disease in metabolic syndrome
  • DOI:
    10.1016/j.atherosclerosis.2005.01.012
  • 发表时间:
    2005-08-01
  • 期刊:
  • 影响因子:
    5.3
  • 作者:
    Nakamura, T;Takano, H;Kugiyama, K
  • 通讯作者:
    Kugiyama, K
Stabilization of carotid atheroma assessed by quantitative ultrasound analysis in nonhypercholesterolemic patients with coronary artery disease
Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression - Involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis
Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease
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KUGIYAMA Kiyotaka其他文献

KUGIYAMA Kiyotaka的其他文献

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{{ truncateString('KUGIYAMA Kiyotaka', 18)}}的其他基金

A study of role of phospholipase A2 receptor in pathogenosis ofcardiovascular diseases and development of new drug for cardiovascular diseases
磷脂酶A2受体在心血管疾病发病机制中的作用研究及心血管疾病新药开发
  • 批准号:
    22390158
  • 财政年份:
    2010
  • 资助金额:
    $ 9.6万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
A study of role of phospholipase A2 in pathogenosis of cardiovascular diseases and development of new drug for cardiovascular diseases
磷脂酶A2在心血管疾病发病中的作用研究及心血管疾病新药开发
  • 批准号:
    19390209
  • 财政年份:
    2007
  • 资助金额:
    $ 9.6万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Role of polymorphisms of γ-glutamylcysteine synthetase genes in pathogenesis of coronary spastic angina
γ-谷氨酰半胱氨酸合成酶基因多态性在冠状动脉痉挛性心绞痛发病机制中的作用
  • 批准号:
    13670728
  • 财政年份:
    2001
  • 资助金额:
    $ 9.6万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Role of oxidative stress in pathogenesis of coronary spasm, a molecular biological and clinical study
氧化应激在冠状动脉痉挛发病机制中的作用,分子生物学和临床研究
  • 批准号:
    11670693
  • 财政年份:
    1999
  • 资助金额:
    $ 9.6万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effects of remnant lipoproteins on functions of endothelial cells, smooth muscle
残余脂蛋白对内皮细胞、平滑肌功能的影响
  • 批准号:
    09670730
  • 财政年份:
    1997
  • 资助金额:
    $ 9.6万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effects of lysolecithin on the regulation of gene transcription in endothelial cells and plasma levels of secretary type II phospholipase A2 in coronary artery disease
溶血卵磷脂对冠心病内皮细胞基因转录及血浆分泌型II型磷脂酶A2水平的影响
  • 批准号:
    07670793
  • 财政年份:
    1995
  • 资助金额:
    $ 9.6万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effects of natriuretic peptides on the mechanisms of atherosclerosis
利钠肽对动脉粥样硬化机制的影响
  • 批准号:
    05670622
  • 财政年份:
    1993
  • 资助金额:
    $ 9.6万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
Effects of oxidized low density lipoprotein on vascular endothelial and smooth muscle cells
氧化低密度脂蛋白对血管内皮和平滑肌细胞的影响
  • 批准号:
    03670460
  • 财政年份:
    1991
  • 资助金额:
    $ 9.6万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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