Novel Genes of Autosomal Recessive Spinocerebellar Degeneration

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In spinocerebeller ataxia (SCA),many causative genes for the dominant forms of SCA have been identified. On the other hand, the most gene for the recessive form of SCA still are unknown. To identify the causative genes for the recessive form of SCA, we analyzed the patient DNA by high density SNP chips, detected the homozygote regions, and sequenced the exons of the coding genes. We didn't detect the significant of the differences of the exons of the genes. We may need the research for the introns of the genes.