Disorder of reward circuit in bipolar disorders : integration of basic and clinical investigation

与精神分裂症相比，双相情感障碍患者的听觉诱发电位和失配负性受损程度较轻。然而，健康志愿者的损伤没有统计学意义。这些标记可以区分双相情感障碍和精神分裂症。此外，血清素转运蛋白基因多态性与双相情感障碍有关。在动物实验中，当受到压力时；心理或免疫，特定的回路受到刺激，包括下丘脑，额叶皮层和边缘奖励系统，而不管刺激的种类。

Auditory evoked potential and mismatch negativity are less impaired in bipolar disorder as compared with schizophrenia. However, impairment was not statistically significant from healthy volunteers. These markers may differential bipolar disorder from schizophrenia. In addition, polymorphism of serotonin transporter genes is associated with bipolar disorder. In animal study, when given stress ; psychological or immunological, particular circuits are stimulated including hypothalamus, frontal cortex, and limbic reward system regardless the kinds of stimuli.