A ROLE OF INTERLEUKIN-1 IN PATHOGENESIS OF MANIC-DEPRESSIVE-ILLNESS

白介素 1 在躁狂抑郁症发病机制中的作用

• 批准号: 08457252
• 负责人: KANBA Shigenobu
• 金额: $ 1.79万
• 依托单位: YAMANASHI MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457252/
• 关键词: manic depressive illness; stress; cytokine; vasopressin; TNF; interleukin; inteferon; インターロイキン-1; インターロイキン-1受容体アンタゴニスト; 視床下部; HPA系

Interleukin-1 (IL-1) and IL-1, receptor antagonist mRNA levels peaked at approximately 0.5 and 2-4 hr, respectively. The maximum mRNA levels of IL-1b were 15-fold higher than pre-immobilization levels, whereas those of IL-1 receptor antagonists were 250-fold higher in the hypothalamus. After the biosynthesis of IL-1b has peaked, IL-1 receptor antagonist may contribute to attenuation of the IL-1 activity which has been enhanced by immobilization.Chronic treatments of psychotropics for 28 days raised the levels of both mRNAs. The increase in IL-1 receptor antagonist mRNA was 6-112 times larger than that of IL-1b mRNA in most brain regions examined. These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL-1 receptor antagonist than IL-1b mRNA in the brain.

白介素1(IL-1)和受体拮抗剂IL-1的mRNA水平分别在0.5小时和2-4小时达到峰值。下丘脑中IL-1b的最大信使核糖核酸水平是制动前的15倍，而IL-1受体拮抗剂的最大信使核糖核酸水平是制动前的250倍。在IL-1b生物合成达到高峰后，IL-1受体拮抗剂可能有助于减弱通过固定而增强的IL-1活性。慢性精神药物治疗28天后，两种mRNAs水平均升高。在大多数脑区，IL-1受体拮抗剂mRNA的增加是IL-1b的6-112倍。这些结果表明，慢性精神药物治疗对脑内IL-1受体拮抗剂的放大作用比对IL-1b基因的放大作用更大。

项目成果

Suzuki,E: "Immobilization stress increases mRNA levels of interleukin-1 receptor omtagonist in various rat brain regions" Cell.Molec.Neurobiol.17・5. 557-562 (1997)

Suzuki, E：“固定应激会增加大鼠不同脑区中白细胞介素 1 受体拮抗剂的 mRNA 水平”Cell.Molec.Neurobiol.17・5 (1997)。

Szuki, E., Shintani, F., Kanba, S., Asai, M., and Nakaki, T.: "Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions." Cell Mol Neurobiol. 17. 557-562 (1997)

Szuki, E.、Shintani, F.、Kanba, S.、Asai, M. 和 Nakaki, T.：“固定应激会增加大鼠不同脑区中白细胞介素 1 受体拮抗剂的 mRNA 水平。”

Suzuki, E: "Immobilization stress increases mRNA levels of interleukin-1 receptor omtagonist in various rat brain regions" Cell.Molec.Neurobiol.17・5. 557-562 (1997)

Suzuki, E：“固定应激会增加大鼠不同脑区中白细胞介素 1 受体拮抗剂的 mRNA 水平”Cell.Molec.Neurobiol.17・5 (1997)。

Suzuki,E et al.: "Immobilization stress incleases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions" Cell.Mol.Neurobiol.(in press).

Suzuki,E 等人：“固定应激会增加大鼠不同脑区中白细胞介素 1 受体拮抗剂的 mRNA 水平”Cell.Mol.Neurobiol.（出版中）。