A ROLE OF INTERLEUKIN-1 IN PATHOGENESIS OF MANIC-DEPRESSIVE-ILLNESS

白细胞介素-1（IL-1）和IL-1受体拮抗剂mRNA水平分别在约0.5和2-4小时达到峰值。IL-1b的最大mRNA水平比固定前水平高15倍，而IL-1受体拮抗剂在下丘脑中高250倍。在IL-1b的生物合成达到高峰后，IL-1受体拮抗剂可能有助于减弱IL-1活性，而IL-1活性已被制动增强。IL-1受体拮抗剂mRNA在大部分脑区的表达量是IL-1b mRNA的6-112倍。这些结果表明，慢性精神药物治疗引起更大的放大作用IL-1受体拮抗剂比IL-1b mRNA在大脑中。

Interleukin-1 (IL-1) and IL-1, receptor antagonist mRNA levels peaked at approximately 0.5 and 2-4 hr, respectively. The maximum mRNA levels of IL-1b were 15-fold higher than pre-immobilization levels, whereas those of IL-1 receptor antagonists were 250-fold higher in the hypothalamus. After the biosynthesis of IL-1b has peaked, IL-1 receptor antagonist may contribute to attenuation of the IL-1 activity which has been enhanced by immobilization.Chronic treatments of psychotropics for 28 days raised the levels of both mRNAs. The increase in IL-1 receptor antagonist mRNA was 6-112 times larger than that of IL-1b mRNA in most brain regions examined. These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL-1 receptor antagonist than IL-1b mRNA in the brain.