Study on functional roles of PBR (TSPO) in glia and myocardium
Study on functional roles of PBR (TSPO) in glia and myocardium
批准号:
19390319
负责人:
INOUE Osamu
金额:
$11.56万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
PK-11195 suppressed the enhancement of glucose metabolism in rat brain induced by infusion of quinolinic acid (QUIN). The enhancement of glucose use induced by QUIN mainly occurred in glial cells, and neuroprotective effect of PK-11195 might be related to the suppression of anaerobic glicolysis in glial cells. Methyl ethyl ketone and diethyl ketone showed significant anticonvulsive and neuroprotective effects in lithium -pilocarpine SE rats, while Ro5-4864 showed only a very weak effect. The binding parameters of PBR in heart, lung and kidney of rats were estimated by employing ^<18>F-FEDAC, which had rapid kinetic properties in these peripheral tissues.
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In vivo monitoring of extracellular 13N-glutamine derived from bloodborne 13N-ammonia in rat striatum using microdialysis with radio-LC method.
使用微透析和放射LC方法对大鼠纹状体中源自血源性13N-氨的细胞外13N-谷氨酰胺进行体内监测。
DOI:
--
发表时间:
2009
期刊:
J Neurosci Methods 184(1)
影响因子:
--
作者:
[Okada M, Nakao R, Hosoi R, Zhang MR, Fukumura T, Suzuki K, Inoue O]
通讯作者:
Inoue O
In vivoマイクロダイアリシスradio-LCを用いたラット線条体細胞外液中13N-アンモニアの動態計測
使用体内微透析放射液相色谱动态测量大鼠纹状体细胞外液中的 13N-氨
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[岡田真希, 中尾隆士, 細井理恵, 張明栄, 入江俊章, 福村利光, 鈴木和年, 井上修]
通讯作者:
井上修
Li-pilocarpineてんかんモデルにおける14C-酢酸取込みの充進について
Li-毛果芸香碱癫痫模型中 14C-乙酸摄取的增强
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[湯川博, 池内真志, 大石幸一, 宮本義孝, 野口洋文, 井上誠, 長谷川護, 生田幸士, 林衆治, 細井 理恵]
通讯作者:
細井 理恵
DOI:
--
发表时间:
2009
期刊:
Ann Nucl Med. 23(3)
影响因子:
--
作者:
[Hirose S, Momosaki S, Sasaki K, Hosoi R, Abe K, Gee A, Inoue O.]
通讯作者:
Inoue O.
イボテン酸注入早期のラット脳における糖代謝の亢進と酸素代謝について
早期注射鹅膏蕈酸后大鼠脑内糖代谢和氧代谢的增强
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[細井理恵, 桃崎壮太郎, 合瀬恭幸, 福田肇, 樋掛正明, 林拓也, 渡部浩司, 三宅義徳, 飯田秀博, 井上修]
通讯作者:
井上修
共 45 条
Mechanism of atherosclerosis progression by platelet CLEC-2
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批准号:18K06912
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项目类别:Grant-in-Aid for Scientific Research (C)
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负责人:INOUE Osamu
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依托单位:
The roles of CLEC-2 in lymphangiogenesis at the sites of inflammation
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Comprehensive study of "Clear Mirror", translated Buddhist history in 17th century Mongolia
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Platelet activation receptor CLEC-2: The role for lung development.
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2011
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依托单位:
Evaluation of 14C(11C)-Benzyl acetate as a potential probe for the measurement of glial metabolism.
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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依托单位:
Application of oncolytic adenovirus to the Exfoliative cytodiagnosis
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批准号:22792015
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2010
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负责人:INOUE Osamu
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依托单位:
The novel platelet activation receptor CLEC-2: The role of CLEC-2 for megakaryopoiesis, platelet production and its signaling mechanism
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2008
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依托单位:
Basic research of the generation mechanism of aerodynamic Noise and its control
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批准号:19360079
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项目类别:Grant-in-Aid for Scientific Research (B)
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财政年份:2007
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依托单位:
Research and study of birch bark manuscripts and the culture of birch bark of the mongols
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.19万
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财政年份:2006
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负责人:INOUE Osamu
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依托单位:
Historical Study in Cultural Contacts and Changes of North/Central Eurasia
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.81万
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财政年份:2004
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负责人:INOUE Osamu
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依托单位:
Basic research of the generation mechanism of aerodynamic noise-Development to complex flow fields and control of the noise-
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批准号:16360085
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2004
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负责人:INOUE Osamu
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依托单位:
Development of RI probe for the measurement of glial metabolism.
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Development of receptor activation method for brain imaging with PET or SPECT
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资助金额:$2.11万
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依托单位:
Basic research of the generation mechanism of aerodynamic noise
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
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依托单位:
Study on the new functional neurotransmision image with PET in intact brain
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项目类别:Grant-in-Aid for Scientific Research (B)
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财政年份:1997
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负责人:INOUE Osamu
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依托单位:
Sound Generation by Interactions among Vortex, Heat and Shock Wave
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批准号:08455086
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.67万
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财政年份:1996
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负责人:INOUE Osamu
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依托单位:
Study of Acoustic Sounds by Computational and Experimental Fluid Dynamics
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批准号:06452172
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.03万
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财政年份:1994
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负责人:INOUE Osamu
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依托单位:
海外基金