The basic study of the effect of biocompatible phospholipid polymer on the osteoarthritis progression

生物相容性磷脂聚合物对骨关节炎进展影响的基础研究

• 批准号: 19390388
• 负责人: MORO Toru
• 金额: $ 11.48万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390388/
• 关键词: 医療・福祉; 生体材料; ナノバイオ; バイオテクノロジー; トランスレーショナルリサーチ

To evaluate the effect of biocompatible phospholipid polymer on the osteoarthritis progression, we used the ball-on-flat machine, which mimicked a natural joint, and the experimental osteoarthritis model. The friction tests using a ball-on-flat machine revealed that phospholipid polymer extremely improved the friction coefficient as compared to water and hyaluronic acid treatment. In addition, phospholipid polymer prevented the osteoarthritis progression in the experimental osteoarthritis model. From these results of the study, we believe that this new technology will prevent the osteoarthritis progression.

为了评价生物相容性磷脂聚合物对骨关节炎进展的影响，我们使用了模拟天然关节的球-平机器和实验性骨关节炎模型。使用球-平机器的摩擦测试显示，与水和透明质酸处理相比，磷脂聚合物极大地改善了摩擦系数。此外，磷脂聚合物在实验性骨关节炎模型中阻止骨关节炎进展。从这些研究结果来看，我们相信这项新技术将阻止骨关节炎的进展。

项目成果

Enhanced wear resistance of orthopaedic bearing due to the cross-linking of poly (MPC) graft chains induced by gamma-rayirradiation

伽玛射线辐照诱导的聚 (MPC) 接枝链交联增强了骨科轴承的耐磨性

• 发表时间: 2008
• 期刊: J Biomed Mater Res B 84
• 作者: Masayuki Kyomoto;et. al.
• 通讯作者: et. al.

Hydration of phosphorylcholine groups attached to highly swollen polymer hydrogels studied by thermal analysis

• DOI: 10.1016/j.polymer.2008.08.025
• 发表时间: 2008-10
• 期刊: Polymer
• 影响因子: 4.6
• 作者: Toshinori Morisaku;J. Watanabe;T. Konno;M. Takai;K. Ishihara

Phosphorylation of, GSK-3p by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.

cGMP 依赖性蛋白激酶 II 磷酸化 GSK-3p 可促进小鼠软骨细胞的肥大分化。

• 发表时间: 2008
• 期刊: J Clin Invest 118
• 作者: Kawasaki Y;et al
• 通讯作者: et al

Antithrombogenic Polymer Alloy with Well-defined Block-type Phospholipid Polymer and Segmented Polyurethane for Cardiovascular Medical Devices

用于心血管医疗器械的具有明确嵌段型磷脂聚合物和嵌段聚氨酯的抗血栓聚合物合金

• 发表时间: 2009
• 作者: Ishihara K;Matsuno R;Konno T;Takai M;Asanuma Y
• 通讯作者: Asanuma Y

変形性関節症の診断と治療 : 最近の進歩

骨关节炎的诊断和治疗：最新进展

• 发表时间: 2009
• 作者: Miyake J;Murase T;Moritomo H;荒木令江;Hirata M;Moritomo H;川口浩
• 通讯作者: 川口浩