Molecular approaches to identify molecules involved in the cell aggregates formation in the skeletal blastema and elucidation of their functional properties

点击翻译按钮获取中文摘要

During skeletal development, the skeletal blastema starts from cell aggregates formation in the mesoderm tissue. To understand skeletal tissue formation, it is crucial to elucidate molecular mechanism how cell aggregates are formed. In this study we aimed to establish molecular approaches to identify functional molecules involved in the cell aggregates formation and to analyze their expressions and functions. Through these approaches, we identified and characterized several molecules that may function in the skeletal blastema.