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Epigenetic changes in cell fate decision during mesenchymal cell differentiation.

Epigenetic changes in cell fate decision during mesenchymal cell differentiation.
间充质细胞分化过程中细胞命运决定的表观遗传变化。
批准号:
23659862
负责人:
NIFUJI Akira
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
We examined epigenetic changes during cell fate change of mesenchyal cells, using 10T1/2fibroblastic cells. Aza-cytidine treatment induced myogenic differentiation whereas HDAC-inhibitor TSA blocked it. TSA also blocked ER-myoD induced myogenesis. Bisulfate sequence and targeted amplicon using sequence next generation reveled that myoD induced myogenin expression does not accompanied with change of CpG methylation irrespective of presence of TSA.
期刊论文(34)
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会议论文
A Simultaneous Space-sampling Method for DNA Fraction Collection Using a Comb Structure in Microfluidic Devices
微流控装置中使用梳状结构的 DNA 组分同步空间采样方法
DOI: 10.1002/elps.201100362
发表时间: 2011
期刊: Electrophoresis
影响因子: 2.9
作者: [Shibata, N., Hayashi, T., Fukumura, R., Fujii, J., Kudome-Takamatsu, T., Nishimura, O., Sano, S., Son, F., Suzuki, N., Araki, R., Abe, M., Agata, K., Zheyu Li]
通讯作者: Zheyu Li
ERK signaling controls blastema cell differentiation during planarian regeneration.
ERK 信号控制涡虫再生过程中胚基细胞的分化。
DOI: 10.1242/dev.060764
发表时间: 2011
期刊: Development
影响因子: 4.6
作者: [Araki R, Hoki Y, Uda M, Nakamura M, Jincho Y, Tamura C, Sunayama M, Ando S, Sugiura M, Yoshida MA, Kasama Y, Abe M, Tasaki Junichi]
通讯作者: Tasaki Junichi
Pre-incubation of whole teeth in collagen gel enrich progenitor cells of mouse periodontal ligament. 第
在胶原凝胶中预孵育整颗牙齿可丰富小鼠牙周膜的祖细胞。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Shimada A, Shibata T, Komatsu K, IdenoH, Nifuji A.]
通讯作者: Nifuji A.
アレンドロネートの細胞内取込みによる骨形成の促進
通过细胞内摄取阿仑膦酸钠促进骨形成
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [小松浩一郎, 島田明美, 出野尚, 柴田達也, 中島和久, 二藤彰]
通讯作者: 二藤彰
25
    Cellular conversion from non- skeletal to skeletal cells by using transactivation MyoD domain
    • 批准号:
      25670784
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2013
    • 负责人:
      NIFUJI Akira
    • 依托单位:
    DNA methylation and histone modification regulate differentiationof skeletal stem cells
    • 批准号:
      22390344
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.23万
    • 财政年份:
      2010
    • 负责人:
      NIFUJI Akira
    • 依托单位:
    Molecular approaches to identify molecules involved in the cell aggregates formation in the skeletal blastema and elucidation of their functional properties
    • 批准号:
      19390475
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.23万
    • 财政年份:
      2007
    • 负责人:
      NIFUJI Akira
    • 依托单位:
    Study on regulation of osteogenesis through BMP antagonists
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