Metabolome analysis of oral biofilm using CE-TOFMS and its application possibility as an oral health indicator

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Metabolome analysis for the representative plaque bacteria and human oral biofilm using a capillary electrophoresis equipped with a time-of-flight mass spectrometer was established. By this method, a new finding was obtained about the pentose-phosphate pathway and the Kreb's tricarboxylic acid cycle, as well as the Embden-Meyerhof-Parnas pathway. In addition, the metabolome analysis was applicable to a very small amount of oral biofilm. These results suggest that the metabolome data can be used as an indicator of oral health status.