Contamination status of antibiotics and spreading of drug-resistance genes in Indochina aquaculture environment

我们对抗生素污染进行了监测，发现磺胺甲恶唑和磺胺甲恶唑可以作为判断污染源的标志物。畜牧场使用的主要是磺胺二甲嘧啶。磺胺抗性基因sul在养殖场、城市运河、水产养殖业中检出频率最高。基因类型以Sul1为主，这与欧洲以Sul2为主不同。这项研究极大地扩展了对抗生素污染和抗生素耐药基因在水环境中传播的认识。

We monitored antibiotic contamination and found that sulfamethazine and sulfamethoxazole could be marker drugs to estimate contamination origin. Animal farm used mainly sulfamethazine. Sulfonamide resistance gene, sul, were detected frequently in animal farm, city canal and fish culture in this order. The genotype sul1 was the majority, which was different from Europe where sul2 is major. This study expanded very much the knowledge of antibiotic contamination and antibiotic resistance gene spreading in aquatic environments.