Contamination status of antibiotics and spreading of drug-resistance genes in Indochina aquaculture environment

我们对抗生素污染进行监测，发现磺胺甲基嗪和磺胺甲恶唑可以作为估计污染来源的标记药物。动物养殖场使用的主要是磺胺乙胺。磺胺耐药基因sul在畜禽养殖场、城市运河和养鱼场中常检出。与以sul2基因型为主的欧洲不同，以sul1基因型为主。这项研究极大地扩展了对抗生素污染和抗生素耐药基因在水生环境中传播的认识。

We monitored antibiotic contamination and found that sulfamethazine and sulfamethoxazole could be marker drugs to estimate contamination origin. Animal farm used mainly sulfamethazine. Sulfonamide resistance gene, sul, were detected frequently in animal farm, city canal and fish culture in this order. The genotype sul1 was the majority, which was different from Europe where sul2 is major. This study expanded very much the knowledge of antibiotic contamination and antibiotic resistance gene spreading in aquatic environments.