Effects of fatty acids on differentiation of neuronal stem cells and the protective and ameliorative effects on dementia.

脂肪酸对神经元干细胞分化的影响以及对痴呆症的保护和改善作用。

• 批准号: 19500324
• 负责人: HASHIMOTO Michio
• 金额: $ 2.83万
• 依托单位: Shimane University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19500324/
• 关键词: 精神・神経疾患の病態と治療; 神経幹細胞; n-3系多価不飽和脂肪酸; 神経新生; ヒト介入試験; ドコサヘキサエン酸; 二重盲検並行群間比較法; ミニメンタルステートテスト; 前頭葉機能試験; 健常高齢者; 認知症予防; 多価不飽和脂肪酸; Neurogenesis; 成体脳

1) Docosahexaenoic acid (DHA) and eicosapentaenoic acid, n-3 polyunsaturated fatty acids, promoted neurogenesis of neuronal stem cells (NSCs) isolated from rat embryos and also adult hippocampus. These n-3 fatty acids induce differentiation by causing cell cycle arrest in NSCs.2) In randomized, double-blind and placebo-controlled trail, preventive effect of DHA supplement for 12 months on cognitive decline rate in elderly people with very mild dementia was observed.

1)二十二碳六烯酸（DHA）和二十碳五烯酸，n-3多不饱和脂肪酸，促进神经干细胞（NSCs）的神经发生从大鼠胚胎和成年海马分离。这些n-3脂肪酸通过引起神经干细胞的细胞周期阻滞来诱导分化。2）在随机、双盲和安慰剂对照试验中，观察了DHA补充剂12个月对极轻度痴呆老年人认知能力下降率的预防作用。

项目成果

ラット視床下部における暑熱暴露による神経新生の加齢変化

大鼠下丘脑热暴露导致的神经发生的年龄相关变化

• 发表时间: 2009
• 作者: 松崎健太郎;片倉賢紀;原俊子;李光華;橋本道男;紫藤治
• 通讯作者: 紫藤治

Carotenoid, tocophetol, and fatty acid biomarkers and dietary intake estimated by using a brief self-administered diet history questionnaire for older Japanese children and adolescents

使用日本年龄较大儿童和青少年的简短自我管理饮食史调查问卷估算类胡萝卜素、生育酚和脂肪酸生物标志物以及饮食摄入量

• 发表时间: 2009
• 期刊: Journal of Nutritional Science of Vitamin 55
• 作者: Masayuki Okuda;Satoshi Sasaki;Noriko Bando;Michio Hashimoto;Ichiro Kunitsugu;Shinichi Sugiyama;Junji Terao;Tatsuya Hobara
• 通讯作者: Tatsuya Hobara

DHA disrupts in vitro amyloid β1-40 fibrillation and concomitantly inhibits amyloid levels in cerebral cortex tissue of Alzheimer's disease model rats.

DHA 破坏体外淀粉样蛋白 β1-40 纤维颤动，同时抑制阿尔茨海默病模型大鼠大脑皮层组织中的淀粉样蛋白水平。

• 发表时间: 2008
• 期刊: Journal of Neurochemistry 107
• 作者: Michio Hashimoto;Hossain Md Shahdat;Shinji Yamashita;Masanori Katakura;Yoko Tanabe;Hironori Fujiwara;Shuji Gamoh;Teruo Miyazawa;Noriyuki Arai;Toshio Shimada;Osamu Shido.
• 通讯作者: Osamu Shido.

POSSIBLE PARTICIPATION OF CHLORIDE ION CHANNELS IN ATP RELEASE FROM CANCER CELLS IN SUSPENSION

• DOI: 10.1111/j.1440-1681.2008.05060.x
• 发表时间: 2009-03
• 期刊: Clinical and Experimental Pharmacology and Physiology
• 影响因子: 2.9
• 作者: N. Nejime;S. Kagota;Y. Tada;Kazuki Nakamura;M. Hashimoto;M. Kunitomo;K. Shinozuka

The protective effect of dietary eicosapentaenoic acid on the impairment of spatial cognition learning ability in amyloid beta _<1-40>-infijsed rats.

膳食二十碳五烯酸对淀粉样β_<1-40>感染大鼠空间认知学习能力损害的保护作用。

• 发表时间: 2009
• 期刊: Journal of Nutritional Biochemistry (印刷中)
• 作者: Michio Hashimoto;Shahdat Hossain;Yoko Tanabe;Akiko Kawashima;Tsuyoshi Harada;Takashi Yano;Kiyoshi Mizuguchi;Osamu Shido
• 通讯作者: Osamu Shido