Multilateral verification of preventive effects of polyunsaturated fatty acids on dementia

从痴呆预防的人类干预研究的子分析中，根据12个月内总MMSE（dMMSE）评分的平均变化将两组细分如下：应答者，总dMMSE评分变化> 0;无应答者，总dMMSE评分变化< 0。应答者血浆LDL-胆固醇和红细胞二十碳五烯酸水平显著高于无应答者，提示老年人的营养状况反映在富含DHA的食物对痴呆的预防作用中。TSQ量子质谱分析表明，DHA对老年大鼠空间认知学习能力的改善与脑内DHA代谢产物水平呈正相关，并建立了海马DHA水平下降的图像质谱分析方法。

From the sub-analysis of human interventional studies on dementia prevention, both the groups were subdivided according to the mean changes in the total MMSE (dMMSE) scores over 12 months as following: responders, total dMMSE change > 0; nonresponders, total dMMSE score change < 0. The levels of plasma LDL-cholesterol and erythrocyte eicosapentaenoic acid were significant higher in the responders than those in the nonresponders, suggesting that the nutrition status of the elderly is reflected in dementia preventive effect by DHA-enriched food. The differences of genetic polymorphisms of delta 5 desaturase were, however, not observed between two groups.Using a TSQ quantum mass spectrometer, the positive correlation between the improvement of spatial cognitive learning ability in DHA-administrated aged rats and the brain levels of DHA-derived metabolites was found. Visualization of decreased DHA in the hippocampus of rats by imaging mass spectrometry was established.