Exploration of causative or marker gene for canine cryptorchidism and application to the genetic diagnosis

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In the present study, in order to identify causative gene or marker gene for canine cryptorchidism, a part (9 single nucleotide polymorphisms in 70kb region from 3'terminal) of estrogen receptor・gene (ESR1) was examined in cryptorchid dogs of small breeds and compared with normal animals. As the results, no clear differences of the frequency of the single nucleotide polymorphisms were found in Miniature Duchshunds and Chihuahuas between cryptorchid and normal dogs. However, frequencies of the polymorphisms of cryptorchid dogs differed with normal animals although the examined number of affected dogs was small, and thus further studies are required to determine the associations between bilateral cryptorchidism and the polymorphism in ESR1.