Exploration of causative or marker gene for canine cryptorchidism and application to the genetic diagnosis

犬隐睾致病基因或标记基因的探索及其在基因诊断中的应用

• 批准号: 19580373
• 负责人: KAWATE Noritoshi
• 金额: $ 2.33万
• 依托单位: Osaka Prefecture University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19580373/
• 关键词: 潜在精巣; イヌ; エストロジェン受容体α遺伝子; 一塩基多型(SNP); ゲノムDNA; 培養精巣細胞; テストステロン分泌

In the present study, in order to identify causative gene or marker gene for canine cryptorchidism, a part (9 single nucleotide polymorphisms in 70kb region from 3'terminal) of estrogen receptor・gene (ESR1) was examined in cryptorchid dogs of small breeds and compared with normal animals. As the results, no clear differences of the frequency of the single nucleotide polymorphisms were found in Miniature Duchshunds and Chihuahuas between cryptorchid and normal dogs. However, frequencies of the polymorphisms of cryptorchid dogs differed with normal animals although the examined number of affected dogs was small, and thus further studies are required to determine the associations between bilateral cryptorchidism and the polymorphism in ESR1.

本研究对小型犬隐睾症的雌激素受体基因（ESR1）的一部分（从3 '端起70kb区域内的9个单核苷酸多态性）进行了检测，并与正常犬进行了比较，以确定犬隐睾症的致病基因或标记基因。结果表明，在小型腊肠犬和吉娃娃犬中，隐睾犬和正常犬的单核苷酸多态性频率无明显差异。然而，隐睾犬的多态性的频率与正常动物不同，虽然受影响的狗的检查数量是小的，因此需要进一步的研究，以确定双侧隐睾症和ESR1的多态性之间的关联。

项目成果

Comparison of Plasma Concentrations of Estradiol-17β and Progesterone, and Conception in Dairy Cows with Cystic Ovarian Diseases between Ovsynch and Ovsynch plus CIDR Timed AI Protocols.

Ovsynch 和 Ovsynch 加 CIDR 定时 AI 方案之间雌二醇-17β 和孕酮的血浆浓度以及患有囊性卵巢疾病的奶牛受孕的比较。

• 发表时间: 2011
• 期刊: Journal of Reproduction and Development 57
• 作者: Kawate N;Watanabe K;Uenaka K;Takahashi M;Inaba T;Tamada H
• 通讯作者: Tamada H

Ovsynch Plus CIDR Protocol for Timed Embryo Transfer in Suckled Postpartum Japanese Black Beef Cows

用于产后日本黑肉牛定时胚胎移植的 Ovsynch Plus CIDR 协议

• 发表时间: 2007
• 期刊: Journal of Reproduction and Development 53
• 作者: Kawate N;Sakase M;Watanabe K;Fukushima M;Noda M;Takeda K;Ueno S;Inaba T;Kida K;Tamada H;Sawada T
• 通讯作者: Sawada T

Comparison of secretory responses of insulin-like peptide 3 and testosterone to hCG in cultured testicular cells of cryptorchid and normal dogs

隐睾和正常犬培养睾丸细胞胰岛素样肽3和睾酮对hCG分泌反应的比较

• 发表时间: 2010
• 作者: Indunil Pathirana;Yukino Ashida;Kakeru Tanaka;Makoto Tsuji;Shingo Hatoya;Toshio Inaba;Masahiro Takahashi;Hiromichi Tamada;Noritoshi Kawate
• 通讯作者: Noritoshi Kawate

第103回日本繁殖生物学会大会講演要旨集

第103届日本生殖生物学会会议摘要

• 发表时间: 2010
• 作者: Indunil Pathirana;Yukino Ashida;Kakeru Tanaka;Makoto Tsuji;Shingo Hatoya;Toshio Inaba;Masahiro Takahashi;Hiromichi Tamada;Noritoshi Kawate
• 通讯作者: Noritoshi Kawate

獣医繁殖学マニュアル(第2版)(第4章犬および猫の6～8の項目p241～257を分担執筆)

兽医育种手册（第二版）（合着第 4 章，狗和猫，第 6 至 8 项，第 241 至 257 页）

• 发表时间: 2007
• 作者: 玉田尋通;川手憲俊;喜田加世子
• 通讯作者: 喜田加世子