Studies on the Molecular Mechanism of Species-specific Recognition in Biological Diversity

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Murine lymphoid neoplastic P388D1 cells were found to have six receptor candidates with the molecular sizes in the range from 130 to 300kDa which discriminate species-specificity among the C-terminal variable regions of heat shock protein 70 (HSP70). We revealed that species-specific diversity contributes in the cell-surface presentation on murine LL/2 lung carcinoma upon non-lethal heat shock, in the binding to CD11b-, CD11c-, or NK1.1-positive innate immune cells, and also in the differentiation to regulatory T cells from nalve T cells.