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Basic studies on the treatment and prevention of hepatocellular carcinoma with interferon

Basic studies on the treatment and prevention of hepatocellular carcinoma with interferon
干扰素治疗和预防肝细胞癌的基础研究
批准号:
19590412
负责人:
YANO Hirohisa
金额:
$1.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
To induce efficient anti-proliferative effect of interferon (IFN) on hepatocellular carcinoma cells, we performed the following investigation : 1) combination of other drugs with IFN, 2) application of new drug delivery system, and 3) determination and functional analysis of the molecules closely related with IFN-mediated apoptosis induction. As a result, combination of IFN with anti-angiogenesis drug was effective to a certain extent. New drug delivery system worked to some extent and may be more effective after some improvement. XAF-1 and TRAIL were closely related with the induction of apoptosis and the regulation of XAF-1 and TRAIL will modify the anti-proliferative effect of IFN.
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Growth inhibitory effects of pegylated IFN-a2b and 5-fluorouracil in combination on renal cell carcinoma cell lines in vitro and in vivo.
聚乙二醇化 IFN-a2b 和 5-氟尿嘧啶联合使用对肾细胞癌细胞系的体外和体内生长抑制作用。
DOI: --
发表时间: 2008
期刊: Int J Oncol 33
影响因子: --
作者: [Moriya F., Ogasawara S., Basaki Y., Akiba J., Kojiro S., Fukahori S., Ishizaki H., Nishida N., Matsuoka K., Kojiro M., Kuwano M., Yano H.]
通讯作者: Yano H.
シグナル伝達分子阻害剤単独あるいはインターフェロンとの併用による肝癌細胞の増殖抑制効果の検討
考察信号转导分子抑制剂单独使用或与干扰素联合使用抑制肝癌细胞生长的效果
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [小笠原幸子, 他]
通讯作者:
DOI: 10.3892/ijmm_00000375
发表时间: 2010-04-01
期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
影响因子: 5.4
作者: [Futami, Kazunobu, Ogasawara, Sachiko, Furuichi, Yasuhiro]
通讯作者: Furuichi, Yasuhiro
肝癌の発生・進展とインターフェロンによる制御
肝癌的发生、发展及干扰素的控制
DOI: --
发表时间: 2008
期刊: J Microwave Surg 26
影响因子: --
作者: [安田純, 前野恵美, 高橋由香里, 橋本健洋, Daub C., 林崎良英, 安田純, Futami Kazunobu, 安田純, Yano H., 安田純, 矢野博久]
通讯作者: 矢野博久
20
    Identification of diagnostic marker of combined hepatocellular-cholangiocarcinoma subtypes by gene expression analysis
    • 批准号:
      18K07032
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.66万
    • 财政年份:
      2018
    • 负责人:
      YANO Hirohisa
    • 依托单位:
    Basic research on anti-tumor effects of Interferon-α on hepatocellular carcinoma
    • 批准号:
      13670233
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.92万
    • 财政年份:
      2001
    • 负责人:
      YANO Hirohisa
    • 依托单位:
    SUTUDIES ON THE RELATIONSHIP BETWEEN EPIDERMAL GROWTH FACTOR FAMILY EXPRESSION AND CARCINIGENESIS AND PROGESSION OF HEPATODELLULAR CRACINOMA : A SPECIAL REFERENCE TO HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH FACTOR EXPRESSION
    • 批准号:
      09670242
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.86万
    • 财政年份:
      1997
    • 负责人:
      YANO Hirohisa
    • 依托单位:
    海外基金