Molecular analysis of Borrelia-binding to tick organs

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1) Using a phage display library of Borrelia garinii DNA, a candidate ligand for tick salivary gland was isolated. Six surface exposure antigen genes were especially estimated as the gene encording borrelial binding factor to tick salivary gland.2) Borrelia sp. tAG, originally isolated from Amblyomma tick, was colonized into tick midgut. In this study, we experimentally confirmed borrelia bound to tick midgut organ. The borrelial binding to tick midgut was inhibited by Collagen-I and some glycosaminoglycans (Dermatan, Heparan and Condroitin).