Monitoring of Inflammatory Markers in Exhaled Breath Condensate in patients with Asthma and Development of Evaluating System of Asthma Severity
哮喘患者呼出气冷凝液中炎症标志物的监测及哮喘严重程度评估系统的开发
基本信息
- 批准号:19590560
- 负责人:
- 金额:$ 2.83万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2007
- 资助国家:日本
- 起止时间:2007 至 2009
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The evaluation of airway inflammation is important for the diagnosis and treatment of asthma. The exhaled breath condensate (EBC) is a less invasive method compared with bronchoalveolar lavage or bronchial biopsy. Measurement of mediators in EBC could be a useful method for monitoring airway inflammation in asthma. The aims of this study are to establish the EBC collection method and to find measurable biomarkers reflecting asthmatic airway inflammation and the relationship between these biomarkers and asthmatic severity and lung function. Fifty-eight non-smoking healthy subjects, 7 asymptomatic smokers, 9 common cold subjects and 55 asthmatics with disease severity ranging from mild intermittent to severe persistent were enrolled. We measured the levels of pH, CRP, albumin, Eosinophil cationic protein (ECP), H_2O_2, and nitrite/nitrate in EBC. The levels of CRP, H_2O_2, nitrite/nitrate of the asthma group were significantly higher than in the control group. In asthmatic severity, the levels of pH, CRP, ECP, H_2O_2 and nitrate in the mild persistent group were significantly higher than the other groups with severity. In addition, the H_2O_2 level in EBC significantly correlated with that of nitrite/nitrate. FEV1 and PEFR showed a significant negative correlation with the levels of ECO, H_2O_2 and nitrite/nitrate. EBC collection is noninvasive and useful to evaluate airway inflammation by measuring inflammatory markers in the management of asthma.
气道炎症的评价对哮喘的诊断和治疗具有重要意义。与支气管肺泡灌洗或支气管活检相比,呼出气冷凝液(EBC)是一种侵入性较小的方法。EBC中介质的测定可能是监测哮喘气道炎症的有用方法。本研究的目的是建立EBC的采集方法,寻找可测量的反映哮喘气道炎症的生物标志物,以及这些生物标志物与哮喘严重程度和肺功能的关系。58名不吸烟的健康受试者、7名无症状吸烟者、9名普通感冒受试者和55名疾病严重程度从轻度间歇性到重度持续性的哮喘患者被纳入。检测EBC中pH、CRP、白蛋白、嗜酸性粒细胞阳离子蛋白(ECP)、H_2O_2和亚硝酸盐/硝酸盐水平。哮喘组CRP、H_2O_2、亚硝酸盐/硝酸盐水平均显著高于对照组。在哮喘严重程度方面,轻度持续组的pH、CRP、ECP、H_2O_2和硝酸盐水平显著高于其他严重程度组。EBC中H_2O_2含量与亚硝酸盐/硝酸盐含量呈显著正相关。FEV 1、PEFR与ECO、H_2O_2、NO_2/NO_3呈显著负相关。EBC采集是无创的,可通过测量哮喘管理中的炎症标志物来评估气道炎症。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice
- DOI:10.1159/000110891
- 发表时间:2008-01-01
- 期刊:
- 影响因子:2.8
- 作者:Ito, Wataru;Tanimoto, Mitsune;Kanehiro, Arihiko
- 通讯作者:Kanehiro, Arihiko
Quantitative analysis of propionibacterial DNA in bronchoalveolar lavage cells from patients with sarcoidosis.
- DOI:
- 发表时间:2008-06
- 期刊:
- 影响因子:0
- 作者:H. Ichikawa;M. Kataoka;J. Hiramatsu;M. Ohmori;Y. Tanimoto;A. Kanehiro;Yasunari Nakata;M. Tanimoto
- 通讯作者:H. Ichikawa;M. Kataoka;J. Hiramatsu;M. Ohmori;Y. Tanimoto;A. Kanehiro;Yasunari Nakata;M. Tanimoto
シンポジウム気管支喘息の難治か機構とその対策「成人喘息の立場から-臨床マーカー-」
研讨会:支气管哮喘的难治机制及对策“从成人哮喘的角度-临床标志物”
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:谷本安、高橋清、片岡幹男;他
- 通讯作者:他
Inflammatory markers in exhaled breath condensate from patients with asthma
哮喘患者呼出气冷凝液中的炎症标志物
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:Ueno T;Kanehiro A;(他8名、6番目)
- 通讯作者:(他8名、6番目)
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KATAOKA Mikio其他文献
KATAOKA Mikio的其他文献
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{{ truncateString('KATAOKA Mikio', 18)}}的其他基金
Development of rapid test for biomarkers in exhaled breath condensate in patients with asthma and its use for the management of asthmatics
哮喘患者呼出气冷凝物生物标志物快速检测方法的开发及其在哮喘治疗中的应用
- 批准号:
22590526 - 财政年份:2010
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Elucidation of protein dynamics as the control of protein function
阐明蛋白质动力学作为蛋白质功能的控制
- 批准号:
20370062 - 财政年份:2008
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Studies on the principle of protein architecture by the simplification of amino acid sequence
从氨基酸序列简化研究蛋白质结构原理
- 批准号:
16370074 - 财政年份:2004
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study for correlation between Sarcoidosis and Propionibacteria and its application to diagnostic method
结节病与丙酸杆菌相关性研究及其在诊断方法中的应用
- 批准号:
15590489 - 财政年份:2003
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Structure, Properties and Function of Photoactive Yellow Protein
光活性黄色蛋白的结构、性质和功能
- 批准号:
13480221 - 财政年份:2001
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular Mechanism of Protein Folding and Functioning by Means of Deletions and Insertions
通过删除和插入实现蛋白质折叠和功能的分子机制
- 批准号:
10480182 - 财政年份:1998
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Experimental and Theoretical Studies on Protein Dynamics and Changes in Dynamics upon Folding
蛋白质动力学和折叠时动力学变化的实验和理论研究
- 批准号:
09044220 - 财政年份:1997
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Structures and Formation Mechanisms of Folding Intermediates of Proteins
蛋白质折叠中间体的结构和形成机制
- 批准号:
06304051 - 财政年份:1994
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)
Dynamic Structural Analyzes of the Photointermediates of Bacteriorhodopsin
细菌视紫红质光中间体的动态结构分析
- 批准号:
05680579 - 财政年份:1993
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Studies of Protein Folding with Gene Manipulation and X-ray Solution Scattering -The Case of Staphylococcal Nuclease-
通过基因操作和 X 射线溶液散射研究蛋白质折叠 - 以葡萄球菌核酸酶为例 -
- 批准号:
02680217 - 财政年份:1990
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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- 批准号:
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