Elucidation of protein dynamics as the control of protein function

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We succeeded to create an functionally active mutant without native structure under physiological condition. Using the mutant and wild type, neutron incoherent scattering experiments were performed under various hydration levels to reveal the protein dynamics required for function. Protein dynamics relevant for function is controlled by hydration water, and the hierarchical structures of protein dynamics are dependent on the conformational states. The essential property of hydration water is revealed to be the formation of hydrogen bond network between hydration water molecules.